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Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
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논문 기본 정보

Type
Academic journal
Author
Kim Jong Hyun (Daegu Catholic University) Lee Chan-Hyeong (Kyungpook National University) Baek Moon-Chang (Kyungpook National University)
Journal
KOREAN SOCIETY OF MEDICAL BIOCHEMISTRY AND MOLECULAR BIOLOGY Experimental and Molecular Medicine Experimental and Molecular Medicine 제54권 KCI Accredited Journals SCI
Published
2022.11
Pages
1 - 11 (11page)
DOI
10.1038/s12276-022-00898-7

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Dissecting exosome inhibitors: therapeutic insights into small-molecule chemicals against cancer
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Abstract· Keywords

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Intensive research in the field of cancer biology has revealed unique methods of communication between cells through extracellular vesicles called exosomes. Exosomes are released from a broad spectrum of cell types and serve as functional mediators under physiological or pathological conditions. Hence, blocking the release of exosome bio carriers may prove useful for slowing the progression of certain types of cancers. Therefore, efforts are being made to develop exosome inhibitors to be used both as research tools and as therapies in clinical trials. Thus, studies on exosomes may lead to a breakthrough in cancer research, for which new clinical targets for different types of cancers are urgently needed. In this review, we briefly outline exosome inhibitors and discuss their modes of action and potential for use as therapeutic tools for cancer.

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