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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제52권 제4호
- 발행연도
- 2022.7
- 수록면
- 465 - 476 (12page)
- DOI
- 10.1007/s40005-022-00574-y
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초록· 키워드
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Purpose The aim of this study was to design and evaluate chitosan nanoparticles (CS NPs) coated with alginate which protect protein drugs from acid degradation.K The model protein drug used was bovine serum albumin (BSA).
Methods BSA-loaded CS NPs (BSA-CS NPs) were prepared using the ionic gelation method with sodium tripolyphosphate and the surface of the BSA-CS NPs were coated with sodium alginate (Alg). The optimized alginate-coated BSA-CS NPs (Alg-BSA-CS NPs) were evaluated for BSA degradation in an acidic medium.
Results The encapsulation efficiency (EE), particle size, polydispersity index, and zeta potential of the prepared Alg-BSACS NPs were 95.2%, 476.4 nm, 0.24, and ? 53.8 mV, respectively. An in vitro release study showed that the initial burst release of BSA from the BSA-CS NPs was higher than that from the Alg-BSA-CS NPs. Cytotoxicity analysis revealed that the Alg-BSA-CS NPs were non-toxic to Caco-2 cells. The in vitro cellular uptake of the Alg-BSA-CS NPs in Caco-2 cells was significantly higher than that of the BSA-CS NPs and free BSA. Sodium dodecyl sulfate?polyacrylamide gel electrophoresis showed that the Alg-BSA-CS NPs protected BSA from degradation in an acidic environment.
Conclusion Alg-BSA-CS NPs are suitable for the oral delivery of protein drugs by preventing protein degradation in acidic environments.
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