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논문 기본 정보

자료유형
학술저널
저자정보
Kim Mi-Yeong (Department of Internal Medicine Inje University Busan Paik Hospital Inje University College of Medi) Jo Eun-Jung (Department of Internal Medicine Pusan National University Hospital Pusan National University Colleg) Kim Sujeong (Department of Internal Medicine School of Medicine Kyungpook National University Daegu Korea.) Kim Min-Hye (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea.) Jung Jae-Woo (Department of Internal Medicine Chung-Ang University College of Medicine Seoul Korea.) Kim Joo-Hee (Department of Internal Medicine Hallym University Sacred Heart Hospital Hallym University College o) Moon Ji-Yong (Department of Internal Medicine Hanyang University Guri Hospital Hanyang University College of Medi) Kwon Jae-Woo (Department of Internal Medicine Kangwon National University School of Medicine Chuncheon Korea.) Lee Jae-Hyun (Division of Allergy and Immunology Department of Internal Medicine Yonsei University College of Med) Park Chan Sun (Department of Internal Medicine Inje University Haeundae Paik Hospital Inje University College of M) Jin Hyun Jung (Department of Internal Medicine Yeungnam University College of Medicine Daegu Korea.) Shin Yoo Seob (Department of Allergy and Clinical Immunology Ajou University School of Medicine Suwon Korea.) Kim Sae-Hoon (Department of Internal Medicine Seoul National University Bundang Hospital Seongnam Korea.) Cho Young-Joo (Department of Internal Medicine College of Medicine Ewha Womans University Seoul Korea.) Park Jung-Won (Division of Allergy and Immunology Department of Internal Medicine Yonsei University College of Med) Cho Sang-Heon (Department of Internal Medicine Seoul National University College of Medicine Seoul Korea.) Kim Tae-Bum (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) Park Hye-Kyung (Department of Internal Medicine Pusan National University Hospital Pusan National University Colleg)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.37 No.7
발행연도
2022.2
수록면
1 - 15 (15page)
DOI
10.3346/jkms.2022.37.e57

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Background: Some reports have suggested that the clinical and economic burdens of asthma are associated with blood eosinophil levels. The association between clinical burden and blood eosinophil counts were evaluated in a Korean adult asthma cohort. Methods: Clinical information including blood eosinophil counts that were not affected by systemic corticosteroids were extracted from the Cohort for Reality and Evolution of Adult Asthma in Korea database. Clinical burden was defined as 1) asthma control status, 2) medication demand and 3) acute exacerbation (AE) events during 1 consecutive year after enrollment. All patients were divided into atopic and non-atopic asthmatics. The associations between asthma outcomes and the blood eosinophil count were evaluated. Results: In total, 302 patients (124 atopic and 178 non-atopic asthmatics) were enrolled. In all asthmatics, the risk of severe AE was higher in patients with blood eosinophil levels < 100 cells/μL than in patients with levels ≥ 100 cells/μL (odds ratio [OR], 5.406; 95% confidence interval [CI], 1.266?23.078; adjusted P = 0.023). Among atopic asthmatics, the risk of moderate AE was higher in patients with blood eosinophil levels ≥ 300 cells/μL than in patients with levels < 300 cells/μL (OR, 3.558; 95% CI, 1.083?11.686; adjusted P = 0.036). Among non-atopic asthmatics, the risk of medication of Global Initiative for Asthma (GINA) steps 4 or 5 was higher in patients with high blood eosinophil levels than in patients with low blood eosinophil levels at cutoffs of 100, 200, 300, 400, and 500 cells/μL. Conclusion: The baseline blood eosinophil count may predict the future clinical burden of asthma.
#Asthma #Blood Eosinophils #Clinical Burden

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