지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.6
- 수록면
- 511 - 519 (9page)
- DOI
- 10.3349/ymj.2022.63.6.511
이용수
초록· 키워드
오류제보하기
Purpose: Monoclonal antibodies against type 2 inflammatory pathways are currently promising therapeutics for severe asthma.
The aim of this study was to determine how well type 2 (T2) inflammation-specific agents targeting interleukins reduce the rate ofasthma exacerbations (AE) in patients with severe asthma.
Materials and Methods: We performed a systematic review and meta-analysis in accordance with PRISMA guidelines. A systematicliterature search was conducted in PubMed, Embase, and the Cochrane Central Register. The primary outcome was the reductionrate of annualized AEs.
Results: We analyzed 17 studies comprising 11800 subjects. A total of 6197 patients received T2-specific agents (benralizumab,dupilumab, lebrikizumab, mepolizumab, reslizumab, and tralokinumab). Overall, T2-specific agents were significantly associatedwith a lower risk of AE, compared with placebo [rate ratio (RR) 0.58, 95% confidence interval (CI) 0.51 to 0.66]. Among all studiedagents, only tralokinumab did not demonstrate a reduction in AE. The efficacy of T2-specific agents in reducing AE was maintainedregardless of the pathway used. A subgroup analysis indicated that T2-specific agents further reduced the risk of AE in patients witheosinophil counts of ≥300 cells/μL (RR 0.41, 95% CI 0.32 to 0.53).
Conclusion: Our findings suggest that T2-specific agents are significantly associated with a reduced rate of AE, compared withplacebo. Their efficacy appears to be enhanced in patients with eosinophil counts of ≥300 cells/μL.
목차
등록된 정보가 없습니다.
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Genetic Signatures of Asthma Exacerbation
Allergy, Asthma & Immunology Research
2017 .01
-
Adverse events associated with third space endoscopy: Diagnosis and management
International Journal of Gastrointestinal Intervention
2020 .01
-
동작관찰 중 동작 수행 시 시점의 변화에 따른 뇌 활성의 변화
PNF and movement
2016 .01
-
A Nationwide Survey of mRNA COVID-19 Vaccinee’s Experiences on Adverse Events and Its Associated Factors
Journal of Korean Medical Science
2023 .06
-
Seasonal Cycle and Relationship of Seasonal Rhino- and Influenza Virus Epidemics With Episodes of Asthma Exacerbation in Different Age Groups
Allergy, Asthma & Immunology Research
2017 .01
-
A Comprehensive Review of the Treatment of Atopic Eczema
Allergy, Asthma & Immunology Research
2016 .01
-
Safety of Tacrolimus in Autoimmune Disease: Results From Post-marketing Surveillance in South Korea
대한류마티스학회지
2021 .10
-
Association Between Clinical Burden and Blood Eosinophil Counts in Asthma: Findings From a Korean Adult Asthma Cohort
Journal of Korean Medical Science
2022 .02
-
An integrated analysis of elbasvir/grazoprevir in Korean patients with hepatitis C virus genotype 1b infection
Clinical and Molecular Hepatology
2019 .01
-
Psychiatric adverse events associated with the COVID-19 vaccines approved in the Republic of Korea: a systematic review
Osong Public Health and Research Persptectives
2024 .04
-
Biological treatments for severe asthma
Journal of Yeungnam Medical Science
2020 .01
-
침구 치료 이상반응 설문지 개발과 타당도 평가
Korean Journal of Acupuncture
2015 .01
-
Genetic Signatures of Acute Asthma Exacerbation Related With Ineffective Response to Corticosteroid
Allergy, Asthma & Immunology Research
2020 .01
-
A Comparison of Mortality and Morbidity Between Complex and Degenerative Spine Surgery in Prospectively Collected Data From 2,280 Procedures
Neurospine
2021 .09
-
Effects of aloe-emodin on alveolar bone in Porphyromonas gingivalis induced periodontitis rat model: a pilot study
Journal of Periodontal & Implant Science
2022 .10
-
Potential use of ashwagandha extract in storage of liquid boar semen
Journal of Biomedical and Translational Research
2024 .06
-
Signal Detection for Cardiovascular Adverse Events of DPP-4 Inhibitors Using the Korea Adverse Event Reporting System Database, 2008–2016
Yonsei Medical Journal
2019 .01
-
Safety of COVID-19 Vaccines among Patients with Type 2 Diabetes Mellitus: Real-World Data Analysis
Diabetes and Metabolism Journal
2023 .05
-
우리나라의 한약 부작용 규모 추정
대한예방한의학회지
2020 .01
-
Signal Detection of Adverse Drug Reaction of Amoxicillin Using the Korea Adverse Event Reporting System Database
Journal of Korean Medical Science
2016 .01
이 논문의 저자 정보
최근 본 자료
댓글(0)
0