Pathomechanism of oxidative stress in cardiovascularrenal remodeling and therapeutic strategies

Ravarotto Verdiana; Bertoldi Giovanni; Stefanelli Lucia Federica; Nalesso Federico; Calò Lorenzo A.

doi:10.23876/j.krcp.22.069

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자료유형: 학술저널

저자정보: Ravarotto Verdiana (Department of Medicine Nephrology Dialysis and Transplantation Unit University of Padova) Bertoldi Giovanni (Department of Medicine Nephrology Dialysis and Transplantation Unit University of Padova) Stefanelli Lucia Federica (Department of Medicine Nephrology Dialysis and Transplantation Unit University of Padova) Nalesso Federico (Department of Medicine Nephrology Dialysis and Transplantation Unit University of Padova) Calò Lorenzo A. (Department of Medicine Nephrology Dialysis and Transplantation Unit University of Padova)

저널정보: 대한신장학회 Kidney Research and Clinical Practice Kidney Research and Clinical Practice Vol.41 No.5

발행연도: 2022.9

수록면: 533 - 544 (12page)

DOI: 10.23876/j.krcp.22.069

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The high prevalence of cardiovascular disease in patients with chronic kidney disease indicates significant interactions between pathogenic pathways operating in the kidney and heart. These interactions involve all cell types (endothelial cells, smooth muscle cells, macrophages, and others), components of the vasculature, glomeruli, and heart that are susceptible to oxidative damage and structural alterations. A vicious cycle occurs whereby harmful factors such as reactive oxygen species and inflammation damage of vascular structures that themselves become sources of additional dangerous/toxic components released into the local environment. The evidence of this vicious cycle in chronic kidney disease should therefore lead to add other factors to both traditional and nontraditional risk factors. This review will examine the processes occurring during progressive kidney dysfunction with regard to vascular injury, renal remodeling, cardiac hypertrophy, and the transversal role of oxidative stress in the development of these complications.

#Antioxidant response elements #Inflammation #Kidney #Reactive oxygen species #Redox balance

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