지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.4
- 수록면
- 123 - 130 (8page)
- DOI
- 10.3341/kjo.2021.0169
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초록· 키워드
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Purpose: To investigate the effects of prostaglandin E2 agonist omidenepag (OMD) on the expression of matrix metalloproteinase(MMP) in human trabecular meshwork (TM) cells.Methods: Primarily cultured human TM cells were exposed to 0, 1, 10, or 40 μmol/L OMD for 3 days. The permeabilitythrough the TM cell monolayer was assessed using carboxyfluorescein. Expressions of messenger ribonucleic acid and proteinlevels of MMP-1, MMP-3, and MMP-9 were measured by reverse transcription polymerase chain reaction and Westernblotting, respectively. Also, the permeability, expression of messenger ribonucleic acid, and protein levels of MMPs weremeasured after exposure to 1 μmol/L latanoprost free acid (LAT).Results: OMD and LAT did not affect the cellular survival (all p > 0.05). Each concentration of OMD and LAT did not affect thepermeability of carboxyfluorescein significantly (all p > 0.05). LAT increased the level of MMP-1 protein but did not increasethe levels of MMP-3 and MMP-9 proteins. Each concentration of OMD did not affect the levels of MMP-1, MMP-3, and MMP-9 proteins (all p > 0.05)Conclusions: In TM cells, prostaglandin E2 agonist OMD did not increase the permeability through the TM cell monolayer,and the protein levels of MMPs. These suggest that the direct effect on the trabecular outflow by OMD may be limited.
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