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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 414 - 421 (8page)
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Purpose: Phosphodiesterase (PDE) inhibitors increase matrix metalloproteinase (MMP) production by inhibitingre-uptake of adenosine and may potentiate nitric oxide (NO) activity. This study was performed to investigatethe effects and mechanisms of PDE inhibitors on trabecular outflow in cultured human trabecular meshworkcells (HTMCs). Methods: Primary HTMC cultures were exposed to 0, 20, and 50 μM dipyridamole (DPD) or theophylline (TPN). Permeability through the HTMC monolayer was assessed using carboxyfluorescein. The production of NOwas assessed using the Griess assay and MMP-2 levels were measured via Western blotting. Results: DPD significantly increased permeability accompanied with increased nitrite concentration and MMP-2levels (all p < 0.05). TPN increased nitrite but did not affect permeability or MMP-2 levels significantly (p > 0.05). When treated with DPD and TPN together, both permeability and nitrite production were increased; however,MMP-2 levels showed no difference compared to DPD exposure alone (p > 0.05). Conclusions: DPD increased trabecular permeability accompanied with increased nitrite production and MMP-2 levels. PDE inhibitors may increase trabecular outflow by increasing MMP-2 levels and by potentiating NOactivity through cyclic GMP in HTMC.
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참고문헌 (35)
참고문헌 신청
Alvarado J / 1984 / Trabecular meshwork cellularity in primary open-angle glaucoma and nonglaucomatous normals / Ophthalmology 91:564~579
Rohen JW / 1993 / Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma(POAG) / Exp Eye Res 56:683~692
Schmidl D / 2015 / Pharmacotherapy of glaucoma / J Ocul Pharmacol Ther 31:63~77
Kopczynski CC / 2014 / Emerging trabecular outflow drugs / J Ocul Pharmacol Ther 30:85~87
Gao ZG / 2011 / Emerging adenosine receptor agonists : an update / Expert Opin Emerg Drugs 16:597~602
Rohen JW / 1993 / Ultrastructure of the trabecular meshwork in untreated cases of primary open-angle glaucoma(POAG) / Exp Eye Res 56:683~692
Schmidl D / 2015 / Pharmacotherapy of glaucoma / J Ocul Pharmacol Ther 31:63~77
Kopczynski CC / 2014 / Emerging trabecular outflow drugs / J Ocul Pharmacol Ther 30:85~87
Gao ZG / 2011 / Emerging adenosine receptor agonists : an update / Expert Opin Emerg Drugs 16:597~602
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