Acupuncture for Osteoporosis: a Review of Its Clinical and Preclinical Studies

Tian Yimiao; Wang Lili; Xu Tianshu; Li Rui; Zhu Ruyuan; Chen Beibei; Zhang Hao; Xia Bingke; Che Yiwen; Zhao Dandan; Zhang Dongwei

doi:10.51507/j.jams.2022.15.5.281

Acupuncture for Osteoporosis: a Review of Its Clinical and Preclinical Studies

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Type: Academic journal

Author: Tian Yimiao (Diabetes Research Center Traditional Chinese Medicine School Beijing University of Chinese Medicine) Wang Lili (Department of TCM Pharmacology Chinese Material Medica School Beijing University of Chinese Medicin) Xu Tianshu (Diabetes Research Center Traditional Chinese Medicine School Beijing University of Chinese Medicine)

Journal: Korea Pharmacopuncture Institute Journal of Acupuncture & Meridian Studies Journal of Acupuncture & Meridian Studies Vol.15 No.5 KCI Accredited Journals

Published: 2022.11

Pages: 281 - 299 (19page)

DOI: 10.51507/j.jams.2022.15.5.281

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Acupuncture for Osteoporosis: a Review of Its Clinical and Preclinical Studies

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Acupuncture has gained growing attention in the management of osteoporosis (OP). However, a comprehensive review has not yet been conducted on the efficacy and challenges of acupuncture in preliminary research and clinical trials. Therefore, an extensive literature search was conducted using electronic databases, including PubMed (www.ncbi.nlm.nih.gov/pubmed), CNKI (www.cnki.net), and Web of Science, for studies published from the beginning of 2000 to the end of May 2022. Combinations of synonyms for OP, acupuncture, traditional Chinese medicine, clinical trial, preclinical study, and animal experiments were searched. A total of 290 papers were consulted, including 115 reviews, 109 clinical observations, and 66 preclinical studies. There is accumulating evidence to support the beneficial role of acupuncture in preserving bone quality and relieving clinical symptoms based on clinical and preclinical investigations. The top ten most commonly used acupoints are BL23, ST36, BL20, BL11, CV4, GV4, SP 6, KI3, BL18, and GB39. The underlying mechanisms behind the benefits of acupuncture may be linked with the regulation of the hypothalamic-pituitary-gonadal (adrenal) axis and activation of the Wnt/β-catenin and OPG/RANKL/RANK signaling pathways. In summary, strong evidence may still come from prospective and well-designed clinical trials to shed light on the potential role of acupuncture in preserving bone loss. Future investigations are needed to explore the potential underlying mechanisms, long-term clinical efficacy, and compliance of acupuncture in OP management.

#Osteoporosis #Acupuncture #Clinical trial #Preclinical study #Clinical investigations

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Tian Yimiao

Affiliation Diabetes Research Center Traditional Chinese Medicine School Beijing University of Chinese Medicine