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논문 기본 정보

자료유형
학술저널
저자정보
Alex Ju Sung Kim (Department of Anatomy and Tumor Immunology Inje University College of Medicine Busan Korea) Sungmoon Ong (Department of Internal Medicine Busan Paik Hospital Inje University College of Medicine Korea) Ji Hyun Kim (Department of Internal Medicine Good Gangan Hospital Busan Korea) Hong Sub Lee (Department of Internal Medicine Busan Paik Hospital Inje University College of Medicine Korea) Jun Sik Yoon (Department of Internal Medicine Busan Paik Hospital Inje University College of Medicine Korea) Dae Young Hur (Department of Anatomy and Tumor Immunology Inje University College of Medicine Busan Korea)
저널정보
대한소화관운동학회(현 대한소화기능성질환.운동학회) Journal of Neurogastroenterology and Motility (JNM) Journal of Neurogastroenterology and Motility (JNM) Vol.28 No.1
발행연도
2022.1
수록면
131 - 144 (14page)
DOI
10.5056/jnm21020

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Background/AimsThe effect of peroral endoscopic myotomy (POEM) on esophageal body movement in achalasia is poorly understood. This study aims to evaluate morphological changes in esophageal body movement after POEM in type III achalasia by analyzing intraluminal ultrasound (US) images in comparison to type I and II achalasia. MethodsIntraluminal US images and impedance values of the distal esophagus from 47 achalasia patients who underwent POEM or pneumatic dilatation (PD) (30 patients in the POEM group and 17 patients in the PD group) with pre- and post-procedural high-resolution impedance manometry and intraluminal US examinations were analyzed. The muscle thickness (MT), muscle cross-sectional area, lumen cross-sectional area (LCSA), contractility and distensibility indices, swallow-to-distension interval, and distension duration during each bolus transport were analyzed. ResultsThe MT increased and LCSA decreased significantly (P < 0.001), but the contractility index was not improved after POEM or PD in type I achalasia. Baseline MT increased and LCSA decreased significantly after POEM and PD in type II achalasia (P < 0.001). In contrast, MT and the swallow-to-distension interval decreased and the distension LCSA/duration and contractility index increased after POEM in type III achalasia (P < 0.001). In contrast to type I and II achalasia, in type III achalasia, these effects were unique to the POEM group. ConclusionsPOEM decreased the esophageal LCSA by decreasing intrabolus pressure without improving contractility in type I and II achalasia. In contrast, POEM increased esophageal body distension and contractility and improved the inhibitory process during bolus transport in type III achalasia.

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