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논문 기본 정보

자료유형
학술저널
저자정보
박소영 (Department of Internal Medicine Chung-Ang University College of Medicine Seoul Korea.Division of Pu) Kang Sung-Yoon (Department of Internal Medicine Gachon University Gil Medical Center Incheon Korea.) Song Woo-Jung (Department of Allergy and Clinical Immunology Asan Medical Center University of Ulsan College of Me) 김주희 (Department of Medicine Hallym University Sacred Heart Hospital Hallym University College of Medicin)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.14 No.5
발행연도
2022.9
수록면
447 - 464 (18page)
DOI
10.4168/aair.2022.14.5.447

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In recent decades, the concept of severe asthma has evolved from an umbrella term encompassing patients with high-intensity treatment needs to a clinical syndrome with heterogeneous, albeit distinct, pathophysiological processes. Biased and unbiased cluster approaches have been used to identify several clinical phenotypes. In parallel, cellular and molecular approaches allow for the development of biological therapies, especially targeting type 2 (T2) cytokine pathways. Although T2-biologics have significantly improved clinical outcomes for patients with severe asthma in real-world practice, questions on the proper use of biologics remain open. Furthermore, a subset of severe asthma patients remains poorly controlled. The unmet needs require a new approach. The “treatable traits” concept has been suggested to address a diversity of pathophysiological factors in severe asthma and overcome the limitations of existing treatment strategies. With a tailored therapy that targets the treatable traits in individual patients, better personalized medical care and outcomes should be achieved.

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