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논문 기본 정보

자료유형
학술저널
저자정보
Jung Sungsu (Department of Pediatrics Pusan National University Yangsan Hospital Yangsan Korea.) Lee So-Yeon (Department of Pediatrics Childhood Asthma Atopy Center Humidifier Disinfectant Health Center Asan M) Yoon Jisun (Department of Pediatrics College of Medicine Chung-Ang University Seoul Korea.) Cho Hyun-Ju (Department of Pediatrics International St. Mary’s Hospital Catholic Kwandong University Incheon Kor) 박민지 (Department of Pediatrics Childhood Asthma Atopy Center Humidifier Disinfectant Health Center Asan M) Song Kun Baek (Department of Pediatrics Soonchunhyang University Cheonan Hospital School of Medicine Soonchunhyang) Choi Eom Ji (Department of Pediatrics Childhood Asthma Atopy Center Humidifier Disinfectant Health Center Asan M) Paek Eun Young (Department of Pediatrics Childhood Asthma Atopy Center Humidifier Disinfectant Health Center Asan M) Yang Song-I (Department of Pediatrics Hallym University Sacred Heart Hospital Hallym University College of Medic) Lee Eun (Department of Pediatrics Chonnam National University Hospital Chonnam National University Medical S) Hong Soo-Jong (Department of Pediatrics Childhood Asthma Atopy Center Humidifier Disinfectant Health Center Asan M)
저널정보
대한천식알레르기학회(구 대한알레르기학회) Allergy, Asthma & Immunology Research Allergy, Asthma & Immunology Research Vol.14 No.5
발행연도
2022.9
수록면
565 - 580 (16page)
DOI
10.4168/aair.2022.14.5.565

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Purpose: Atopic dermatitis (AD) and food allergy (FA) are associated with respiratory comorbidities, in the concept of ‘atopic march.’ However, children with AD and a coexisting FA have various disease courses, and the mechanism of atopic march remains unclear. In this study, we investigated whether the phenotype of AD with coexisting FA in early life affected asthma or allergic rhinitis (AR) in school children. Methods: A total of 1,579 children from the Panel Study on Korean Children (PSKC) cohort were followed-up in 2013. The participants diagnosed with AD in this cohort were classified by the age of AD onset and persistence as well as FA history. We compared the presence of comorbidities—asthma and rhinitis—among different AD phenotypes. Results: Asthma and AR with current symptoms within 12 months at age 6–8 years were associated with early-onset persistent AD phenotype, regardless of coexisting FA. AD with FA conferred a higher risk of recent wheezing at 8 years of age than AD without FA (adjusted odds ratio, 8.09; 95% confidence interval, 2.54–25.76). Children with early-onset persistent AD with FA manifested a distinctive trajectory with a higher prevalence of wheezing and AR at age 5–8 years than those without AD. Conclusions: AD with FA in early life is strongly associated with asthma and AR in school children, and the early-onset persistent AD with FA had a strong additive effect on the risk of asthma at school age. Classifying AD phenotypes regarding FA in early life will help predict and prevent asthma and AR in school children.

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