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논문 기본 정보

자료유형
학술저널
저자정보
Gorsler Anna (Kliniken Beelitz GmbH Clinic for Neurological Rehabilitation Beelitz-Heilstätten Germany.) Grittner Ulrike (Institute of Biometry and Clinical Epidemiology Charité-Universitätsmedizin Berlin Berlin Germany.B) Rackoll Torsten (BIH-QUEST Center for Responsible Research Charité-Universitätsmedizin Berlin Berlin Germany.) Külzow Nadine (Kliniken Beelitz GmbH Clinic for Neurological Rehabilitation Beelitz-Heilstätten Germany.)
저널정보
대한뇌신경재활학회 뇌신경재활 뇌신경재활 제15권 제2호
발행연도
2022.7
수록면
1 - 18 (18page)
DOI
10.12786/bn.2022.15.e19

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초록· 키워드

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Different transcranial direct current stimulation (tDCS) protocols have been tested to improve visuospatial neglect (VSN). So far, methodological heterogenity limits reliable conclusions about optimal stimualtion set-up. With this proof-of-principle study behavioral effects of two promising (uni- vs. bilateral) stimulation protocols were directly compared to gain more data for an appropriate tDCS protocol in subacute neglect patients. Notably, each tDCS set-up was combined with an identical sham condition to improve comparability. In a double-blind sham-controlled cross-over study 11 subacute post-stroke neglect patients received 20 minutes or 30 seconds (sham) tDCS (2 mA, 0.8 A/m2) parallel to neglect therapy randomized in unilateral (anode-reference: P4-Fp2 10-20 electroencephalography [EEG] system) and bilateral manner (anode-cathode: P4-P3) and 48h wash-out in-between. Before and immediately after stimulation performance were measured in cancellation task (bell test), and line bisection (deviation error). Significant difference between active and assigned sham condition was found in line bisection but not cancellation task. Particularly, deviation error was reduced after bilateral tDCS (hedges g* = 0.6) compared to bilateral sham, no such advantage were obtained for unilateral stimulation (hedges g* = 0.2). Using a direct comparison approach findings add further evidence that stimulating both hemispheres (bilateral) is superior in alleviating VSN symptoms than unilateral stimulation in subacute neglect.

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