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논문 기본 정보

자료유형
학술저널
저자정보
Kijeong Lee (Department of Neurology National Health Insurance Service Ilsan Hospital Goyang) Jung-Kyu Choi (Health Insurance Research Institute National Health Insurance Service Wonju) Jin-su Park (Division of Rheumatology Department of Internal Medicine National Health Insurance Service Ilsan Ho) Jung Yoon Pyo (Division of Rheumatology Department of Internal Medicine Yonsei University College of Medicine Seou) Minkyung Han (Biostatistics Collaboration Unit Department of Biomedical Systems Informatics Yonsei University Col) Jun Hong Lee (Department of Neurology National Health Insurance Service Ilsan Hospital Goyang)
저널정보
대한임상노인의학회 임상노인의학회지 임상노인의학회지 제23권 제2호
발행연도
2022.12
수록면
96 - 114 (19page)
DOI
10.15656/kjcg.2022.23.2.96

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Background: Inflammation is an important mechanism in stroke. To a considerable extent, the pathophysiology of inflammatory arthritis is influenced by inflammatory cells and cytokines. We compared the risk of stroke between patients with inflammatory arthritis and matched controls, using data from the National Health Insurance Service. Methods: Using a combination of primary diagnosis and V codes for rare incurable diseases, we defined the patients with ankylosing spondylitis, seropositive rheumatoid arthritis, and psoriatic arthritis and enteropathic spondyloarthropathy. The control group was defined by 1:5 propensity score-matching for each disease. Newly developed stroke was identified in the patients with the primary diagnosis of (I60-64) and 1) brain imaging or 2) a prescription of stroke medication or related intervention. Results: The occurrence of stroke was more frequently associated with seropositive rheumatoid arthritis in both the patient population and the seropositive rheumatoid arthritis control group (hazard ratio 1:11, 95% CI 1.02-1.20, P=0.012). In this study, the frequency of stroke occurrence was not associated with the diagnosis of ankylosing spondylitis nor psoriatic arthritis or enteropathic spondyloarthropathy. Furthermore, the use of biologic agents was not associated with the occurrence of stroke, using multivariable analyses in the three different types of inflammatory arthritis and their respective control groups. Conclusion: Seropositive rheumatoid arthritis was a predictor of frequent stroke occurrences. The patients with seropositive rheumatoid arthritis must be cautious with regard to the occurrence of a comorbid stroke. Further studies with long-term follow-ups of clinical outcomes are warranted to explain the underlying correlation between inflammatory arthritis and the risk of stroke.

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