지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2022.7
- 수록면
- 116 - 125 (10page)
이용수
초록· 키워드
오류제보하기
Background: Although there are growing demands for stem cell-based therapy for companion animals in various diseases, a few clinical trials have been reported. Moreover, most of them are the results from only one or a few times of stem cell injection.
Objectives: The aim of this study is to describe a long-term treatment with allogeneic adipose-derived stem cells (ASCs) in a dog with rheumatoid arthritis (RA), which is a rare canine disease.
Methods: The dog with RA received intravascular injection of allogeneic ASCs derived from two healthy donors once a month for 11 months. To assess therapeutic effects of ASCs, orthopedic examination and clinical evaluation was performed. Cytokines of tumor necrosis factor-α and interleukin-6 in the plasma were measured using ELISA analysis.
Results: Despite this repeated and long-term administration of allogeneic ASCs, there were no side effects such as immunorejection responses or cell toxicity. The orthopedic examination score for the dog decreased after ASCs treatment, and the clinical condition of the dog and owner’s satisfaction were very good
Conclusions: Although ASCs has been suggested as one of the options for RA treatment because of its anti-inflammatory and immunosuppressive functions, it has never been used to treat RA in dogs. The present report describes a case of canine RA treated with allogeneic ASCs for long-term in which the dog showed clinical improvement without adverse effects.
Objectives: The aim of this study is to describe a long-term treatment with allogeneic adipose-derived stem cells (ASCs) in a dog with rheumatoid arthritis (RA), which is a rare canine disease.
Methods: The dog with RA received intravascular injection of allogeneic ASCs derived from two healthy donors once a month for 11 months. To assess therapeutic effects of ASCs, orthopedic examination and clinical evaluation was performed. Cytokines of tumor necrosis factor-α and interleukin-6 in the plasma were measured using ELISA analysis.
Results: Despite this repeated and long-term administration of allogeneic ASCs, there were no side effects such as immunorejection responses or cell toxicity. The orthopedic examination score for the dog decreased after ASCs treatment, and the clinical condition of the dog and owner’s satisfaction were very good
Conclusions: Although ASCs has been suggested as one of the options for RA treatment because of its anti-inflammatory and immunosuppressive functions, it has never been used to treat RA in dogs. The present report describes a case of canine RA treated with allogeneic ASCs for long-term in which the dog showed clinical improvement without adverse effects.
목차
ABSTRACT
INTRODUCTION
MATERIALS AND METHODS
RESULTS
DISCUSSION
REFERENCES
참고문헌 (0)
참고문헌 신청함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Lung Disease in Rheumatoid Arthritis
대한류마티스학회지
2016 .01
-
Clinical characteristics of osteoporosis in patients with rheumatoid arthritis: Disease activity matters
Osteoporosis and Sarcopenia
2020 .01
-
Development of Rheumatoid Nodules after Anti-Tumor Necrosis Factor-α Treatment with Adalimumab for Rheumatoid Arthritis
Annals of Dermatology
2016 .01
-
Physical Activity and Prevalence of Rheumatoid Arthritis in Korean Adults with Prediabetes in the 2009-2013 National Health Cohort Study
한국임상약학회지
2019 .01
-
The efficacy evaluation of rheumatoid arthritis through SS-261 patch by MRI
한국실험동물학회 학술발표대회 논문집
2016 .08
-
Transplantation of adipose derived mesenchymal stem cells for acute thoracolumbar disc disease with no deep pain perception in dogs
Journal of Veterinary Science
2016 .03
-
Rheumatoid arthritis modeling in cynomolgus monkeys
한국실험동물학회 학술발표대회 논문집
2016 .08
-
The effect of a tourmanium ceramic in the aspect of alleviating rheumatoid arthritis
한국실험동물학회 학술발표대회 논문집
2019 .01
-
Rheumatoid Arthritis and Malignancy: What Should We Do With DMARDs?
대한류마티스학회지
2022 .10
-
Placental growth factor mediates rheumatoid arthritis by regulating TH17 production and angiogenesis
한국실험동물학회 학술발표대회 논문집
2020 .07
-
A Challenging Target: Persistent Pain During the Remission State in Rheumatoid Arthritis Patients
대한류마티스학회지
2023 .01
-
Add-on Clarithromycin and Tacrolimus Treatment for Rheumatoid Arthritis
대한류마티스학회지
2017 .01
-
건강보험 청구자료를 이용한 한국인 염증성 관절염 환자의 뇌졸중 발생 분석
임상노인의학회지
2022 .12
-
Interstitial Granulomatous Dermatitis Associated with Rheumatoid Arthritis
Annals of Dermatology
2016 .01
-
Importance of Time-integrated Cumulative Parameters for Radiographic Progression Prediction of Rheumatoid Arthritis
대한류마티스학회지
2022 .07
-
Longitudinal cone beam computed tomography follow-up of rheumatoid arthritis in the temporomandibular joint
Oral Biology Research
2015 .01
-
Applications of stem cells for curing pulmonary diseases
한국실험동물학회 학술발표대회 논문집
2018 .01
-
MTX loaded nanoparticles (MTX-NPs) ameliorate rheumatoid arthritis by simultaneously upregulation of Treg and Breg
한국실험동물학회 학술발표대회 논문집
2022 .07
-
Unusual, but important, peri- and extra-articular manifestations of rheumatoid arthritis: a pictorial essay
ULTRASONOGRAPHY
2021 .10
-
A Case of Rheumatoid Nodules Involving the Larynx
대한이비인후-두경부외과학회지
2019 .01
이 논문의 저자 정보
이 논문과 함께 이용한 논문
최근 본 자료
댓글(0)
0
UCI(KEPA) : I410-ECN-0101-2023-528-001317394