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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.2
- 수록면
- 143 - 150 (8page)
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Homologous recombination (HR) is necessary for maintenance of genomic integrity and prevention of various mutations in tumor suppressor genes and proto-oncogenes. Rad51 and Rad54 are key HR factors that cope with replication stress and DNA breaks in eukaryotes. Rad51 binds to single-stranded DNA (ssDNA) to form the presynaptic filament that promotes a homology search and DNA strand exchange, and Rad54 stimulates the strand-pairing function of Rad51. Here, we studied the molecular dynamics of Rad51 and Rad54 during the cell cycle of HeLa cells. These cells constitutively express Rad51 and Rad54 throughout the entire cell cycle, and the formation of foci immediately increased in response to various types of DNA damage and replication stress, except for caffeine, which suppressed the Rad51-dependent HR pathway. Depletion of Rad51 caused severe defects in re-sponse to postreplicative stress. Accordingly, HeLa cells were arrested at the G2?M transition although a small amount of Rad51 was steadily maintained in HeLa cells. Our results suggest that cell cycle progression and proliferation of HeLa cells can be tightly controlled by the abundance of HR proteins, which are essential for the rapid response to postreplicative stress and DNA damage stress.
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참고문헌 (27)
참고문헌 신청
Blow, J. J. / 2008 / Replication licensing and cancer—a fatal entanglement? / Nat. Rev. Cancer 8:799~806
Branzei, D. / 2010 / Maintaining genome stability at the replication fork / Nat. Rev. Mol. Cell Biol 11:208~219
Cejka, P. / 2010 / DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2 / Nature 467:112~116
Chen, F. / 1997 / Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52 / Mutat. Res 384:205~211
Hong, S. G. / 2013 / The logic and mechanism of homologous recombination partner choice / Mol. Cell 51:440~453
Branzei, D. / 2010 / Maintaining genome stability at the replication fork / Nat. Rev. Mol. Cell Biol 11:208~219
Cejka, P. / 2010 / DNA end resection by Dna2-Sgs1-RPA and its stimulation by Top3-Rmi1 and Mre11-Rad50-Xrs2 / Nature 467:112~116
Chen, F. / 1997 / Cell cycle-dependent protein expression of mammalian homologs of yeast DNA double-strand break repair genes Rad51 and Rad52 / Mutat. Res 384:205~211
Hong, S. G. / 2013 / The logic and mechanism of homologous recombination partner choice / Mol. Cell 51:440~453
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