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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.4
- 수록면
- 271 - 279 (9page)
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Ran-binding protein family member, RanBP9 has been reported in various basic cellular mechanisms and neuropathological conditions including schizophrenia. Previous studies have reported that RanBP9 is highly expressed in the mammalian brain and retina; however, the role of RanBP9 in retinal development is largely unknown. Here, we present the novel and regulatory roles of RanBP9 in retinal devel-opment of a vertebrate animal model, zebrafish. Zebrafish embryos exhibited abundant expression of ranbp9 in developing brain tissues as well as in the developing retina. Yeast two-hybrid screening demonstrated the interaction of RanBP9 with Mind bomb, a component of Notch signaling involved in both neurogenesis and neural disease autism. The interaction is further substantiated by co-localization studies in cultured cells. Knockdown of ranbp9 resulted in retinal dysplasia with defective proliferation of retinal cells, downregulation of neuronal differentiation marker huC, elevation of neural proliferation marker her4, and alteration of cell cycle marker p57kip2. Expression of the Muller glial cell marker glutamine synthase was also affected in knockdown morphants. Our results suggest that Mind bomb-binding partner RanBP9 plays a role during retinal cell de-velopment of zebrafish embryogenesis.
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참고문헌 (28)
참고문헌 신청
Avanesov, A. / 2004 / Approaches to study neurogenesis in the zebrafish retina / Methods Cell Biol 76:333~384
Bae, J. S. / 2015 / Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia / Mol. Med. Rep 11:2975~2980
Bernardos, R. L. / 2005 / Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina / Dev. Biol 278:381~395
Dyer, M. A. / 2000 / p57(Kip2)regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina / Development 127:3593~3605
Dyer, M. A. / 2001 / Regulating proliferation during retinal development / Nat. Rev. Neurosci 2:333~342
Bae, J. S. / 2015 / Investigating the potential genetic association between RANBP9 polymorphisms and the risk of schizophrenia / Mol. Med. Rep 11:2975~2980
Bernardos, R. L. / 2005 / Notch-Delta signaling is required for spatial patterning and Müller glia differentiation in the zebrafish retina / Dev. Biol 278:381~395
Dyer, M. A. / 2000 / p57(Kip2)regulates progenitor cell proliferation and amacrine interneuron development in the mouse retina / Development 127:3593~3605
Dyer, M. A. / 2001 / Regulating proliferation during retinal development / Nat. Rev. Neurosci 2:333~342
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