지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2016.2
- 수록면
- 136 - 140 (5page)
이용수
초록· 키워드
오류제보하기
Eph receptors and their ligands, ephrins, mediate cell-to-cell contacts in a specific brain region and their bi-directional signaling is implicated in the regulation of apoptosis during early brain development. In this report, we used the alpha(?)-Cre transgenic line to induce ephrin-A5 over-expression in the distal region of the neural retina. Using this double transgenic embryo, we show that the over-expression of ephrin-A5 was responsible for inducing massive apoptosis in both the nasal and temporal retinas. In addition, the number of differentiated retinal neurons with the exception of the bipolar neuron was significantly reduced, whereas the laminar organization of the mature retina remained intact. Consistent with this finding, an analysis of the mature retina revealed that the size of the whole retina? particularly the nasal and temporal regions?is markedly reduced. These results strongly suggest that the level of ephrin-A5 expression plays a role in the regulation of the size of the retinal progenitor pool in the neural retina.
목차
등록된 정보가 없습니다.
참고문헌 (16)
참고문헌 신청
Cepko, C. L. / 1996 / Cell fate determination in the vertebrate retina / Proc. Natl. Acad. Sci. USA 93:589~595
Depaepe, V. / 2005 / Ephrin signalling controls brain size by regulating apoptosis of neural progenitors / Nature 435:1244~1250
Kim, Y. / 2013 / Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development / Dev. Neurobiol 73:702~712
Klein, R. / 2014 / Ephrin signalling in the developing nervous system / Curr. Opin. Neurobiol
Lupo, G. / 2005 / Dorsoventral patterning of the Xenopus eye : a collaboration of Retinoid, Hedgehog and FGF receptor signaling / Development 132:1737~1748
Depaepe, V. / 2005 / Ephrin signalling controls brain size by regulating apoptosis of neural progenitors / Nature 435:1244~1250
Kim, Y. / 2013 / Expression of EphA8-Fc in transgenic mouse embryos induces apoptosis of neural epithelial cells during brain development / Dev. Neurobiol 73:702~712
Klein, R. / 2014 / Ephrin signalling in the developing nervous system / Curr. Opin. Neurobiol
Lupo, G. / 2005 / Dorsoventral patterning of the Xenopus eye : a collaboration of Retinoid, Hedgehog and FGF receptor signaling / Development 132:1737~1748
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Identification of an Enhancer Critical for the ephirn-A5 Gene Expression in the Posterior Region of the Mesencephalon
Molecules and Cells
2017 .06
-
EphB/ephrinB Signaling in Cell Adhesion and Migration
Molecules and Cells
2015 .01
-
Cereblon Regulates LPS-induced TNF-alpha and MCP-1 through AMPK/ HO-1 Activation in Retina
한국미생물학회 학술대회논문집
2019 .04
-
Decrease of alpha-crystallin A by miR-325-3p in retinal cells under blue light exposure
Molecules and Cells
2024 .01
-
MiR-339 attenuates LPS-induced intestinal epithelial cells inflammatory responses and apoptosis by targeting TLR4
Genes & Genomics
2020 .01
-
Human Photoreceptor-based Optical Sensor with Human-like Spectral Sensitivities
한국진공학회 학술발표회초록집
2019 .08
-
Characterization and functional analysis of Krtap11-1 during hair follicle development in Angora rabbits (Oryctolagus cuniculus)
Genes & Genomics
2020 .01
-
H9 Induces Apoptosis via the Intrinsic Pathway in Non-Small-Cell Lung Cancer A549 Cells
Journal of Microbiology and Biotechnology
2015 .01
-
Mind Bomb-Binding Partner RanBP9 Plays a Contributory Role in Retinal Development
Molecules and Cells
2017 .04
-
Induction of Apoptosis through ER Stress by Shiga Toxins in Human Retinal Pigment Epithelial Cell
한국미생물학회 학술대회논문집
2017 .04
-
Light microscopic evidence of in vivo differentiation from the transplanted inferior turbinate-derived stem cell into the rod photoreceptor in degenerating retina of the mouse
한국현미경학회지
2020 .01
-
Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina
Nutrition Research and Practice
2020 .06
-
Centella asiatica extract prevents visual impairment by promoting the production of rhodopsin in the retina
Nutrition Research and Practice
2020 .06
-
Picropodophyllotoxin Induces G1 Cell Cycle Arrest and Apoptosis in Human Colorectal Cancer Cells via ROS Generation and Activation of p38 MAPK Signaling Pathway
Journal of Microbiology and Biotechnology
2021 .12
-
WNT Signaling in Lung Repair and Regeneration
Molecules and Cells
2020 .01
-
Artificial Rod and Cone Photoreceptors with Human-Like Spectral Sensitivities; Towards Artificial Retina Technology
한국진공학회 학술발표회초록집
2018 .08
-
Soluble Prokaryotic Expression and Purification of Bioactive Tumor Necrosis Factor-Related Apoptosis-Inducing Ligand
Journal of Microbiology and Biotechnology
2017 .01
-
생쥐 뇌세포에 알코올이 미치는 영향
대한임상검사과학회지
2015 .01
-
Hippo Signaling Circuit and Divergent Tissue Growth in Mammalian Eye
Molecules and Cells
2018 .03
이 논문의 저자 정보
최근 본 자료
댓글(0)
0