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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.9
- 수록면
- 613 - 620 (8page)
- DOI
- 10.14348/molcells.2017.0096
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초록· 키워드
오류제보하기
The most common form of senile dementia is Alzheimer’s disease (AD), which is characterized by the extracellular deposition of amyloid ?-peptide (A?) plaques and the intracellular formation of neurofibrillary tangles (NFTs) in the cerebral cortex. Tau abnormalities are commonly observed in many neurodegenerative diseases including AD, Parkinson’s disease, and Pick’s disease. Interestingly, tau-mediated formation of NFTs in AD brains shows better correlation with cognitive impairment than A? plaque ac-cumulation; pathological tau alone is sufficient to elicit frontotemporal dementia, but it does not cause AD. A growing amount of evidence suggests that soluble A? oligomers in concert with hyperphosphorylated tau (pTau) serve as the major pathogenic drivers of neu-rodegeneration in AD. Increased A? oligomers trigger neuronal dysfunction and network alternations in learning and memory circuitry prior to clinical onset of AD, leading to cognitive decline. Furthermore, accumulated damage to mitochondria in the course of aging, which is the best-known nongenetic risk factor for AD, may collaborate with soluble A? and pTau to induce synapse loss and cognitive impairment in AD. In this review, I summarize and discuss the current knowledge of the molecular and cellular biology of AD and also the mechanisms that underlie A?-mediated neurodegeneration.
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등록된 정보가 없습니다.
참고문헌 (98)
참고문헌 신청
Arendt, T. / 2009 / Synaptic degeneration in Alzheimer's disease / Acta Neuropathol 118:167~179
Bai, X. C. / 2015 / An atomic structure of human γ-secretase / Nature 525:212~217
Ballatore, C. / 2007 / Tau-mediated neurodegeneration in Alzheimer's disease and related disorders / Nat. Rev. Neurosci 8:663~672
Bartus, R. T. / 1982 / The cholinergic hypothesis of geriatric memory dysfunction / Science 217:408~414
Bateman, R. J. / 2011 / Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease / Alzheimers Res. Ther 3:1
Bai, X. C. / 2015 / An atomic structure of human γ-secretase / Nature 525:212~217
Ballatore, C. / 2007 / Tau-mediated neurodegeneration in Alzheimer's disease and related disorders / Nat. Rev. Neurosci 8:663~672
Bartus, R. T. / 1982 / The cholinergic hypothesis of geriatric memory dysfunction / Science 217:408~414
Bateman, R. J. / 2011 / Autosomal-dominant Alzheimer's disease: a review and proposal for the prevention of Alzheimer's disease / Alzheimers Res. Ther 3:1
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