지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.10
- 수록면
- 737 - 751 (15page)
- DOI
- 10.14348/molcells.2017.0069
이용수
초록· 키워드
오류제보하기
Histone-modifying enzymes are key players in the field of cellular differentiation. Here, we used GSK-J4 to profile important target genes that are responsible for neural differentiation. Embryoid bodies were treated with retinoic acid (10 ?M) to induce neural differentiation in the presence or absence of GSK-J4. To profile GSKJ4-target genes, we performed RNA sequencing for both normal and demethylase-inhibited cells. A total of 47 and 58 genes were up- and down-regulated, respectively, after GSK-J4 exposure at a log2-fold-change cut-off value of 1.2 (p-value < 0.05). Functional annotations of all of the differentially expressed genes revealed that a significant number of genes were associated with the suppression of cellular proliferation, cell cycle progression and induction of cell death. We also identified an enrichment of potent motifs in selected genes that were differentially expressed. Additionally, we listed upstream tran-scriptional regulators of all of the differentially expressed genes. Our data indicate that GSK-J4 affects cellular biology by inhibiting cellular proliferation through cell cycle suppression and induction of cell death. These findings will expand the current understanding of the biology of histone-modifying enzymes, thereby promoting further investigations to elucidate the underlying mechanisms.
목차
등록된 정보가 없습니다.
참고문헌 (61)
참고문헌 신청
Bolger, A. M. / 2014 / Trimmomatic : a flexible trimmer for Illumina sequence data / Bioinformatics 30:2114~2120
Burgold, T. / 2008 / The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment / PLoS One 3:e3034
Chen, C. / 2013 / Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways / Int. J. Oncol 42:1113~1119
Chen, Y. / 2016 / microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway / Oncotarget 7:41306~41319
Cho, H. J. / 2010 / Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor / J. Biol. Chem 285:25500~25505
Burgold, T. / 2008 / The histone H3 lysine 27-specific demethylase Jmjd3 is required for neural commitment / PLoS One 3:e3034
Chen, C. / 2013 / Leptin stimulates ovarian cancer cell growth and inhibits apoptosis by increasing cyclin D1 and Mcl-1 expression via the activation of the MEK/ERK1/2 and PI3K/Akt signaling pathways / Int. J. Oncol 42:1113~1119
Chen, Y. / 2016 / microRNA-374a suppresses colon cancer progression by directly reducing CCND1 to inactivate the PI3K/AKT pathway / Oncotarget 7:41306~41319
Cho, H. J. / 2010 / Gadd45b mediates Fas-induced apoptosis by enhancing the interaction between p38 and retinoblastoma tumor suppressor / J. Biol. Chem 285:25500~25505
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