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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 976 - 985 (10page)
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초록· 키워드
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Iron is an essential divalent ion for aerobic life. Life has evolved to maintain iron homeostasis for normal cellular and physiological functions and therefore imbalances in iron levels exert a wide range of consequences. Responses to iron dysregulation in blood development, however, remain elusive. Here, we found that iron homeostasis is critical for differentiation of Drosophila blood cells in the larval hematopoietic organ, called the lymph gland. Supplementation of an iron chelator, bathophenanthroline disulfate (BPS) results in an excessive differentiation of the crystal cell in the lymph gland. This phenotype is recapitulated by loss of Fer1HCH in the intestine, indicating that reduced levels of systemic iron enhances crystal cell differentiation. Detailed analysis of Fer1HCH-tagged-GFP revealed that Fer1HCH is also expressed in the hematopoietic systems. Lastly, blocking Fer1HCH expression in the mature blood cells showed marked increase in the blood differentiation of both crystal cells and plasmatocytes. Thus, our work suggests a relevance of systemic and local iron homeostasis in blood differentiation, prompting further in-vestigation of molecular mechanisms underlying iron regulation and cell fate determination in the hematopoietic system.
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참고문헌 (48)
참고문헌 신청
Agaisse, H. / 2004 / The roles of JAK/STAT signaling in Drosophila immune responses / Immunol. Rev 198:72~82
Benmimoun, B. / 2012 / Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila / Development 139:1713~1717
Brownlie, J. C. / 2009 / Evidence for metabolic provisioning by a common invertebrate endosymbiont, Wolbachia pipientis, during periods of nutritional stress / PLoS Pathog 5:e100036
Cronin, S. J. / 2009 / Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection / Science 325:340~343
De Domenico, I. / 2008 / Regulation of iron acquisition and storage: consequences for iron-linked disorders / Nat. Rev. Mol. Cell Biol 9:72~81
Benmimoun, B. / 2012 / Dual role for Insulin/TOR signaling in the control of hematopoietic progenitor maintenance in Drosophila / Development 139:1713~1717
Brownlie, J. C. / 2009 / Evidence for metabolic provisioning by a common invertebrate endosymbiont, Wolbachia pipientis, during periods of nutritional stress / PLoS Pathog 5:e100036
Cronin, S. J. / 2009 / Genome-wide RNAi screen identifies genes involved in intestinal pathogenic bacterial infection / Science 325:340~343
De Domenico, I. / 2008 / Regulation of iron acquisition and storage: consequences for iron-linked disorders / Nat. Rev. Mol. Cell Biol 9:72~81
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