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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 한국약제학회 Journal of Pharmaceutical Investigation Journal of Pharmaceutical Investigation 제51권 제6호
- 발행연도
- 2021.11
- 수록면
- 767 - 776 (10page)
- DOI
- 10.1007/s40005-021-00546-8
이용수
초록· 키워드
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Purpose Loganin, one of the two main iridoid glycosides in Cornus officinalis Sieb et Zucc, has been reported to exhibit many biological activities such as immune modulation, as well as anti-inflammatory and anti-shock effects. This study was designed to evaluate the pharmacokinetics of loganin, administered intravenously (5, 10, 20 and 50 mg/kg) and orally (20, 50, 100 and 200 mg/kg), in rats.
Methods To evaluate its hepatic and gastrointestinal first-pass effects, loganin was administered intraportally, intragastrically and intraduodenally to rats.
Results Following intravenous administration of 5?50 mg/kg loganin, a linear relationship was observed between the total area under the plasma concentration?time curve from zero to infinity (AUC) and loganin dose, with ~ 19% of the administered dose excreted in the urine. AUCs following oral administration of 20?200 mg/kg loganin were dose-independent, with the extent of absolute oral bioavailability (F) being approximately 4.87%. The AUC of loganin was significantly lower by 90.6% after intraduodenal than intraportal administration, but did not differ between intragastric and intraduodenal administration.
The AUC was also significantly lower by 52.7% after intraportal, compared to intravenous, administration, suggesting that the hepatic first-pass effect on loganin after entering the portal vein was approximately 4.95% of the oral dose.
Conclusion Taken together, our data suggest that the low F of loganin in rats was due exclusively to its high intestinal firstpass metabolism.
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참고문헌 (33)
참고문헌 신청
Himanshu Kumar Bhakta / 2016 / Kinetics and molecular docking studies of loganin, morroniside and 7-O-galloyl-D-sedoheptulose derived from Corni fructus as cholinesterase and b-secretase 1 inhibitors / Archives of Pharmacal Research 39(6):794~805
Cao G / 2012 / Screening and identification of potential active components in crude Fructus Corni using solid-phase extraction and LC-LTQ-linear ion trap mass spectrometry / Pham Biol 50:278~283
Chen L / 2017 / Determining concentration of loganin in plasma of rat by UPLC-MS/MS method: applications for a pharmacokinetic study / Lat Am J Pharm 36:2374~2378
Chiou WL / 1978 / Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level–time curve / J Pharmacokinet Biopharm 6:539~546
Davies B / 1993 / Physiological parameters in laboratory animals and humans / Pharm Res 10:1093~1095
Cao G / 2012 / Screening and identification of potential active components in crude Fructus Corni using solid-phase extraction and LC-LTQ-linear ion trap mass spectrometry / Pham Biol 50:278~283
Chen L / 2017 / Determining concentration of loganin in plasma of rat by UPLC-MS/MS method: applications for a pharmacokinetic study / Lat Am J Pharm 36:2374~2378
Chiou WL / 1978 / Critical evaluation of the potential error in pharmacokinetic studies of using the linear trapezoidal rule method for the calculation of the area under the plasma level–time curve / J Pharmacokinet Biopharm 6:539~546
Davies B / 1993 / Physiological parameters in laboratory animals and humans / Pharm Res 10:1093~1095
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