지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 368 - 375 (8page)
- DOI
- 10.5668/JEHS.2020.46.4.368
이용수
초록· 키워드
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Objectives: Some animal studies have reported that methyl mercury causes developmental toxicities such as placental and fetal weight loss, but the mechanism is still unclear. This study aimed to investigate the developmental toxicities of methyl mercury, focusing on placental endocrine function and fetal growth retardation in rats.
Methods: Positively same-time-mated female Sprague-Dawley rats were purchased on gestational day (GD) eight and treated with 0, 5, 10 and 20 ppm of methyl mercury (n=5) dissolved in tap water from GD eight through 19. During treatment, the drinking water (methyl mercury) intake and body weight of each pregnant rat was measured daily. On day 19, caesarean sections were performed and blood samples were collected.
Developmental data such as placental and fetal weights, fetus numbers, and placental efficiency (fetal weight/ placental weight) were also collected. Placental prolactin-growth hormone (PRL-GH) family, such as placental lactogen (PL) -Iv, II, and prolactin-like protein (PLP) -B, levels in serum were analyzed by ELISA. Also, placental tissues were assigned to histochemistry.
Results: The mean cumulative methyl mercury exposure for the 5, 10, and 20 ppm groups were 2.37, 4.63, and 9.66 mg, respectively. The mean daily exposure of the 5, 10, and 20 ppm groups were 0.24, 0.47, and 0.97 mg, respectively. Maternal body weight increased in accordance with GD. There was no significant difference in weight gain among the experimental groups. Histopathologic changes were not observed in placental tissues among the experimental groups. However, mean placental and fetal weights were lower in the 10 and 20 ppm exposed groups compared to the control. Placental efficiency was also lower in the 10 and 20 ppm exposed groups compared to the control. Serum PL-Iv and II levels were lower in the 10 and 20 ppm exposed groups than the control, in accordance with the changing pattern of placental and fetal weights and placental efficiency.
Conclusion: The inhibitory effects of methyl mercury on the serum levels of placental PRL-GH family such as PL-Iv and II may be secondary leads to the reduction of placental efficiency and fetal growth retardation in rats.
목차
등록된 정보가 없습니다.
참고문헌 (32)
참고문헌 신청
Stacey NH / 1980 / Comparison of the effects of metals on cellular injury and lipid peroxidation in isolated rat hepatocytes / J Toxicol Environ Health 7:139~147
Roman HA / 2011 / Evaluation of the cardiovascular effects of methylmercury exposures : current evidence supports development of a doseresponse function for regulatory benefits analysis / Environ Health Perspect 119:607~614
NIER (National Institute of Environmental Research) / 2018 / Annual report of the National Environmental Health Survey (KoNEHS)
NIER (National Institute of Environmental Research) / 2012 / Annual report of the National Environmental Health Survey (KoNEHS)
Rice DC / 2003 / Methods and rationale for derivation of a reference dose for methylmercury by the U.S. EPA / Risk analysis : an official publication of the Society for Risk Analysis 23:107~115
Roman HA / 2011 / Evaluation of the cardiovascular effects of methylmercury exposures : current evidence supports development of a doseresponse function for regulatory benefits analysis / Environ Health Perspect 119:607~614
NIER (National Institute of Environmental Research) / 2018 / Annual report of the National Environmental Health Survey (KoNEHS)
NIER (National Institute of Environmental Research) / 2012 / Annual report of the National Environmental Health Survey (KoNEHS)
Rice DC / 2003 / Methods and rationale for derivation of a reference dose for methylmercury by the U.S. EPA / Risk analysis : an official publication of the Society for Risk Analysis 23:107~115
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