지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.6
- 수록면
- 245 - 258 (14page)
- DOI
- 10.5668/JEHS.2021.47.3.245
이용수
초록· 키워드
오류제보하기
Objectives: In many previous studies, endocrine disruptors (EDCs) have been found to affect delays in puberty.
Various EDCs have been reported on, but there have been only limited epidemiologic studies on the effects of exposure to environmental heavy metals and pyrethroid pesticides on puberty delay. Therefore, the aim of this study was to investigate the association of exposure to environmental mercury, cadmium, and pyrethroid pesticides with delayed puberty in children based on national survey data that represents Korean children.
Methods: We selected 450 children at the ages of 9-11 years old from the third Korean National Environmental Health Survey (3rd KoNEHS). The relations of urinary Hg, Cd, and 3-PBA with pubertal development were evaluated using multiple logistic regression analyses.
Results: Urinary Hg levels were significantly associated with delayed puberty in boys [testicle development: OR=0.41 (95% CI: 0.20, 0.84); genitalia development: OR=0.35 (95% CI: 0.15, 0.81)]. Girls with higher Hg levels were more likely to experience delayed menarche [OR=0.23 (95% CI: 0.06, 0.90)]. We observed a significant 49% reduction in odds for menarche per increasing unit of urinary cadmium levels [OR=0.51 (95% CI: 0.24, 1.01)]. In addition, urinary 3-PBA showed a negative association with genitalia development in boys and menarche in girls [genitalia development: OR=0.73 (95% CI: 0.55, 0.96); menarche: OR=0.56 (95% CI: 0.32, 1.00)].
Conclusions: The results of this study support the hypothesis that exposure to environmental mercury, cadmium and pyrethroid pesticides may affect puberty delays. Additional evidence needs to be obtained through further prospective studies.
목차
등록된 정보가 없습니다.
참고문헌 (36)
참고문헌 신청
Golub MS / 2008 / Public health implications of altered puberty timing / Pediatrics 121(Supplement 3):S218~S230
Bonjour JP / 2014 / Pubertal timing, bone acquisition, and risk of fracture throughout life / Endocr Rev 35(5):820~847
Prentice P / 2013 / Pubertal timing and adult obesity and cardiometabolic risk in women and men : a systematic review and meta-analysis / Int J Obes(Lond) 37(8):1036~1043
Biro FM / 2003 / Pubertal maturation in girls and the relationship to anthropometric changes : pathways through puberty / J Pediatr 142(6):643~647
Finkelstein JS / 1996 / A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty / J Clin Endocrinol Metab 81(3):1152~1155
Bonjour JP / 2014 / Pubertal timing, bone acquisition, and risk of fracture throughout life / Endocr Rev 35(5):820~847
Prentice P / 2013 / Pubertal timing and adult obesity and cardiometabolic risk in women and men : a systematic review and meta-analysis / Int J Obes(Lond) 37(8):1036~1043
Biro FM / 2003 / Pubertal maturation in girls and the relationship to anthropometric changes : pathways through puberty / J Pediatr 142(6):643~647
Finkelstein JS / 1996 / A longitudinal evaluation of bone mineral density in adult men with histories of delayed puberty / J Clin Endocrinol Metab 81(3):1152~1155
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