지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.9
- 수록면
- 166 - 174 (9page)
- DOI
- 10.5045/br.2021.2021111
이용수
초록· 키워드
오류제보하기
Background Thrombotic events are well documented in primary erythrocytosis, but it is uncertain if secondary etiologies increase the risk of thrombosis. This study aimed to determine the causes of erythrocytosis and to identify its impact as a risk factor for thrombosis.
Methods Data were obtained from patients with erythrocytosis between 2000 and 2017 at a referral hospital in Mexico City. Erythrocytosis was defined according to the 2016 WHO classification. Time to thrombosis, major bleeding, or death were compared among groups of patients defined by the etiology of erythrocytosis using a Cox regression model, adjusting for cardiovascular risk factors.
Results In total, 330 patients with erythrocytosis were studied. The main etiologies of erythrocytosis were obstructive sleep apnea (OSA) in 29%, polycythemia vera (PV) in 18%, and chronic lung disease (CLD) in 9.4% of the patients. The incidence rate of thrombosis was significantly higher in patients with PV and CLD than that in patients with OSA (incidence rates of 4.51 and 6.24 vs. 1.46 cases per 100 person-years, P=0.009), as well as the mortality rate (mortality rates of 2.72 and 2.43 vs. 0.17 cases per 100 person-years, P=0.003).
Conclusion The risk of thrombosis in CLD with erythrocytosis was comparable to that in patients with PV. Further larger-scale studies are needed to confirm these findings and evaluate the benefits of preventive management of COPD with erythrocytosis similar to PV
목차
등록된 정보가 없습니다.
참고문헌 (19)
참고문헌 신청
Wouters HJCM / 2020 / Erythrocytosis in the general population : clinical characteristics and association with clonal hematopoiesis / Blood Adv 4:6353~6363
Mithoowani S / 2020 / Investigation and management of erythrocytosis / CMAJ 192:E913~E918
Titmarsh GJ / 2014 / How common are myeloproliferative neoplasms? A systematic review and meta-analysis / Am J Hematol 89:581~587
Mehta J / 2014 / Epidemiology of myeloproliferative neoplasms in the United States / Leuk Lymphoma 55:595~600
Nadeem O / 2013 / Prevalence of venous thromboembolism in patients with secondary polycythemia / Clin Appl Thromb Hemost 19:363~366
Mithoowani S / 2020 / Investigation and management of erythrocytosis / CMAJ 192:E913~E918
Titmarsh GJ / 2014 / How common are myeloproliferative neoplasms? A systematic review and meta-analysis / Am J Hematol 89:581~587
Mehta J / 2014 / Epidemiology of myeloproliferative neoplasms in the United States / Leuk Lymphoma 55:595~600
Nadeem O / 2013 / Prevalence of venous thromboembolism in patients with secondary polycythemia / Clin Appl Thromb Hemost 19:363~366
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