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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제4호
- 발행연도
- 2017.7
- 수록면
- 365 - 373 (9page)
- DOI
- https://doi.org/10.4132/jptm.2017.05.04
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초록· 키워드
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Background: Yes-associated protein (YAP) in the Hippo signaling pathway is a growth control pathway that regulates cell proliferation and stem cell functions. Abnormal regulation of YAP was reported in human cancers including liver, lung, breast, skin, colon, and ovarian cancer. However, the function of YAP is not known in prostate adenocarcinoma. The purpose of this study was to investigate the role of YAP in tumorigenesis, differentiation, and prognosis of prostate adenocarcinoma. Methods: The nuclear and cytoplasmic expression of YAP was examined in 188 cases of prostate adenocarcinoma using immunohistochemistry. YAP expression levels were evaluated in the nucleus and cytoplasm of the prostate adenocarcinoma and the adjacent normal prostate tissue. The presence of immunopositive tumor cells was evaluated and interpreted in comparison with the patients’ clinicopathologic data. Results: YAP expression levels were not significantly different between normal epithelial cells and prostate adenocarcinoma. However, YAP expression level was significantly higher in carcinomas with a high Gleason grades (8?10) than in carcinomas with a low Gleason grades (6?7) (p < .01). There was no statistical correlation between YAP expression and stage, age, prostate-specific antigen level, and tumor volume. Biochemical recurrence (BCR)?free survival was significantly lower in patients with high YAP expressing cancers (p = .02). However high YAP expression was not an independent prognostic factor for BCR in the Cox proportional hazards model. Conclusions: The results suggested that YAP is not associated with prostate adenocarcinoma development, but it may be associated with the differentiation of the adenocarcinoma. YAP was not associated with BCR.
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참고문헌 (35)
참고문헌 신청
Diallo JS / 2008 / Co-assessment of cytoplasmic and nuclear androgen receptor location in prostate specimens : potential implications for prostate cancer development and prognosis / BJU Int 101:1302~1309
정재영 / 2017 / Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea / Cancer Research and Treatment 49(3):607~615
Zhang L / 2015 / The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells / Mol Cell Biol 35:1350~1362
Epstein JI / 2005 / The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma / Am J Surg Pathol 29:1228~1242
McMenamin ME / 1999 / Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage / Cancer Res 59:4291~4296
정재영 / 2017 / Current Trends in the Incidence and Survival Rate of Urological Cancers in Korea / Cancer Research and Treatment 49(3):607~615
Zhang L / 2015 / The hippo pathway effector YAP regulates motility, invasion, and castration-resistant growth of prostate cancer cells / Mol Cell Biol 35:1350~1362
Epstein JI / 2005 / The 2005 International Society of Urological Pathology (ISUP) Consensus Conference on Gleason Grading of Prostatic Carcinoma / Am J Surg Pathol 29:1228~1242
McMenamin ME / 1999 / Loss of PTEN expression in paraffin-embedded primary prostate cancer correlates with high Gleason score and advanced stage / Cancer Res 59:4291~4296
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