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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2020.8
- 수록면
- 177 - 183 (7page)
- DOI
- 10.15188/kjopp.2020.08.34.4.177
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초록· 키워드
오류제보하기
The Hippo-YAP signaling pathway is critical for cell proliferation, survival, and self-renewal in both Drosophila and mammals. Disorder of Hippo-YAP pathway leads to tumor development, progression and poor prognosis in various cancers. YAP/TAZ are the key downstream effectors of the Hippo pathway and they can be inhibited through LATS1/2, core kinases in the Hippo pathway, mediated phosphorylation. In this study, we investigated the effect of Angelica gigas Nakai extract (AGNE) on Hippo-YAP/TAZ pathway. First, ANGE induced YAP/TAZ phosphorylation and dissociation of the YAP/TAZ-TEAD transcription complex. By qRT-PCR, we found that ANGE inhibits the expression of YAP/TAZ-TEAD target gene, CTGF and CYR61. In addition, the transcriptional activity of YAP/TAZ was not suppressed significantly in LATS1/2 double-knockout (DKO) cells by ANGE compared to LATS1/2 wild-type (WT) cells, which means AGNE inhibits YAP/TAZ signaling through direct action on LATS1/2. Further, it was confirmed that AGNE-induced activation of LATS1/2 inhibited the migration potential of the vector-expressing cells by suppressing YAP/TAZ activity. The reduced migration potential was restored in active YAP-TEAD expressing cells. Taken together, the results of this study indicate that ANGE downregulates YAP/TAZ signaling in cells through the activation of LATS1/2.
목차
서론
재료 및 방법
결과
고찰
References
참고문헌 (29)
참고문헌 신청
Dong J / 2007 / Elucidation of a universal size-control mechanism in Drosophila and mammals / Cell 130(6):1120~1133
Pan D / 2010 / The hippo signaling pathway in development and cancer / Developmental cell 19(4):491~505
Harvey KF / 2013 / The Hippo pathway and human cancer / Nature reviews Cancer 13(4):246~257
Johnson R / 2014 / The two faces of Hippo : targeting the Hippo pathway for regenerative medicine and cancer treatment / Nature reviews Drug discovery 13(1):63~79
Mo JS / 2014 / The Hippo signaling pathway in stem cell biology and cancer / EMBO reports 15(6):642~656
Pan D / 2010 / The hippo signaling pathway in development and cancer / Developmental cell 19(4):491~505
Harvey KF / 2013 / The Hippo pathway and human cancer / Nature reviews Cancer 13(4):246~257
Johnson R / 2014 / The two faces of Hippo : targeting the Hippo pathway for regenerative medicine and cancer treatment / Nature reviews Drug discovery 13(1):63~79
Mo JS / 2014 / The Hippo signaling pathway in stem cell biology and cancer / EMBO reports 15(6):642~656
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UCI(KEPA) : I410-ECN-0101-2020-519-001172627