HER2 Status and Its Heterogeneity in Gastric Carcinoma of Vietnamese Patient

Dang Anh Thu Phan; Vu Thien Nguyen; Thi Ngoc Ha Hua; Quoc Dat Ngo; Thi Phuong Thao Doan; Sao Trung Nguyen; Anh Tu Thai; Van Thanh Nguyen

doi:https://doi.org/10.4132/jptm.2017.04.24

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자료유형: 학술저널

저자정보: Dang Anh Thu Phan (University of Medicine and Pharmacy Ho Chi Minh City) Vu Thien Nguyen (University of Medicine and Pharmacy Ho Chi Minh City) Thi Ngoc Ha Hua (University of Medicine and Pharmacy Ho Chi Minh City) Quoc Dat Ngo (University of Medicine and Pharmacy Ho Chi Minh City) Thi Phuong Thao Doan (University of Medicine and Pharmacy Ho Chi Minh City) Sao Trung Nguyen (University of Medicine and Pharmacy Ho Chi Minh City) Anh Tu Thai (Ho Chi Minh City Oncology Hospital) Van Thanh Nguyen (Ho Chi Minh City Oncology Hospital)

저널정보: 대한병리학회 Journal of Pathology and Translational Medicine Journal of Pathology and Translational Medicine 제51권 제4호

발행연도: 2017.7

수록면: 396 - 402 (7page)

DOI: https://doi.org/10.4132/jptm.2017.04.24

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Background: Human epidermal growth factor receptor 2 (HER2) is related to the pathogenesis and poor outcome of numerous types of carcinomas, including gastric carcinoma. Gastric cancer patients with HER2 positivity have become potential candidates for targeted therapy with trastuzumab. Methods: We investigated 208 gastric cancer specimens using immunohistochemistry (IHC), fluorescence in situ hybridization and dual in situ hybridization (ISH). We also investigated the concordance between IHC and ISH. The correlation between HER2 status and various clinicopathological findings was also investigated. Results: In total, 15.9% (33/208) and 24.5% (51/208) of gastric cancers showed HER2 gene amplification and protein overexpression, respectively. A high level of concordance between ISH and IHC analyses (91.3%, κ = 0.76) was found. A significant correlation between HER2 status and intestinal-type (p < .05) and differentiated carcinomas (p < .05) was also noted. The HER2 heterogeneity was high in gastric cancers; we found 68.8% phenotypic heterogeneity and 57.6% genotypic heterogeneity. Heterogeneity in HER2 protein expression and gene amplification showed a close association with diffuse histologic type and IHC 2+. Conclusions: HER2 protein overexpression and gene amplification were detected in 24.5% and 15.9% of gastric cancer specimens, respectively. Intestinal-type showed a higher level of HER2 protein overexpression and gene amplification than diffuse type. HER2 status also showed a significant relationship with well- and moderately-differentiated carcinomas. The ratio of phenotypic and genotypic heterogeneity of HER2 was high in gastric carcinomas and was associated with HER2 IHC 2+ and diffuse histologic type.

#Protein HER2 #Stomach neoplasms #Protein overexpression #Immunohistochemistry #Gene amplification #Fluorescence in situ hybridization #Dual-color silver in situ hybridization

참고문헌 (24)

참고문헌 신청

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Kuo CY / 2014 / Update on treatment of gastric cancer / J Chin Med Assoc 77:345~353

Bang YJ / 2010 / Trastuzumab in combination with chemotherapy versus chemotherapy alone fortreatment of HER2-positive advanced gastric or gastro-oesophageal junction cancer (ToGA): a phase 3, open-label, randomised controlled / Lancet 376:687~697

Zaczek A / 2005 / The diverse signaling network of EGFR, HER2, HER3 and HER4 tyrosine kinase receptors and the consequences for therapeutic approaches / Histol Histopathol 20:1005~1015

Wolff AC / 2013 / Recommendations for human epidermal growth factor receptor 2 testing in breast cancer: American Society of Clinical Oncology/College of American Pathologists clinical practice guideline update / J Clin Oncol 31:3997~4013

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