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논문 기본 정보

자료유형
학술저널
저자정보
Shayanfar, Nasrin (Oncopathology Research Center, Iran University of Medical Sciences) Bahari, Leila (Department of Pathology, Iran University of Medical Sciences) Safaie-Naraghi, Zahra (Department of Pathology, Razi Hospital, Tehran University of Medical Sciences) Kamyab, Kambiz (Department of Pathology, Razi Hospital, Tehran University of Medical Sciences) Gheytanchi, Elmira (Oncopathology Research Center, Iran University of Medical Sciences) Rezaei, Nima (Research Center for Immunodeficiencies, Children's Medical Center, Tehran University of Medical Sciences)
저널정보
아시아태평양암예방학회 Asian Pacific journal of cancer prevention : APJCP Asian Pacific journal of cancer prevention : APJCP 제16권 제2호
발행연도
2015.1
수록면
421 - 425 (5page)

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Background: This study was performed to evaluate the amplification of HER-2/neu in patients with melanoma. Materials and Methods: Amplification of HER-2/neu was evaluated in a group of patients with melanoma, referred to two referral centers in Tehran, using immunohistochemistry (IHC) and chromogenic in situ hybridization (CISH) techniques. Results: Forty patients with mean age $57.9{\pm}19.5years$ were enrolled in this study. The most frequent type of melanoma was acral, while lower limbs were the most frequent sites. The amplification of HER2/neu was negative in 97.5% of patients with IHC and in 100% of patients with CISH technique. Only one case (2.5%) shows weak positive staining (+2) in IHC method. Fifty five percent of melanoma was ulcerative, and the most common stages of tumors were stages 4b and 3b. More than 47% of cases were in Clark level III, while the mean of Breslow thickness was $3.56{\pm}2.87mm$. The stage of the case that showed weakly positive staining (2+) in IHC was 4b. Conclusions: The amplification of HER2/neu biomarker was negative in patients with melanoma, using both CISH and IHC techniques.

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