Metoclopramide for Milk Production in Lactating Women: A Systematic Review and Meta-Analysis

Nik Hazlina Nik Hussain; Norhayati Mohd. Noor; Shaiful Bahari Ismail; Nur Amirah Zainuddin; Zaharah Sulaiman

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자료유형: 학술저널

저자정보: Nik Hazlina Nik Hussain (Universiti Sains Malaysia) Norhayati Mohd. Noor (Universiti Sains Malaysia) Shaiful Bahari Ismail (Universiti Sains Malaysia) Nur Amirah Zainuddin (Universiti Sains Malaysia) Zaharah Sulaiman (Universiti Sains Malaysia)

저널정보: 대한가정의학회 Korean Journal of Family Medicine Korean Journal of Family Medicine 제42권 제6호

발행연도: 2021.11

수록면: 453 - 463 (11page)

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Background: Breastfeeding is recognized as the optimal form of nutrition for the physical and neurological devel-opment of infants and is considered the most significant way to prevent child mortality. This study aimed to assess the effectiveness of metoclopramide for enhancing milk production in lactating women.Methods: We searched the Cochrane Central Register of Controlled Trials and MEDLINE for randomized con-trolled trials comparing metoclopramide with a placebo, no treatment, or other galactagogue drugs. We included breastfeeding women with term or preterm infants.Results: We retrieved 164 records from our search of the electronic databases and 20 records from other sources. Eight trials involving 342 lactating women that used metoclopramide were included in this review after assessing the eligibility criteria. The meta-analysis of these trials revealed that metoclopramide did not increase the milk vol-ume of the intervention groups compared to that of the control groups. There was a significant increase in the se-rum concentrations of prolactin when the mothers were administered metoclopramide. No significant adverse events were reported.Conclusion: Metoclopramide did not improve milk production in lactating women. Therefore, we do not recom-mend using metoclopramide to increase milk production in lactating women.

#Breast Feeding #Lactation #Galactagogues #Metoclopramide

참고문헌 (25)

참고문헌 신청

Bhandari N / 2008 / Mainstreaming nutrition into maternal and child health programmes: scaling up of exclusive breastfeeding / Matern Child Nutr 4(Suppl 1):5~23

World Health Organization / 2003 / Global strategy for infant and young child feeding / World Health Organization

Amir LH / 2014 / Managing common breastfeeding problems in the community / BMJ 348:g2954

Stuebe AM / 2014 / Enabling women to achieve their breastfeeding goals / Obstet Gynecol 123:643~652

Wagner EA / 2013 / Breastfeeding concerns at 3 and 7 days postpartum and feeding status at 2months / Pediatrics 132:e865~e875

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