Polyarthralgia and Myalgia Syndrome after ChAdOx1 nCOV-19 Vaccination

Hyun Hakjun; Song Joon Young; Seong Hye; Yoon Jin Gu; Noh Ji Yun; Cheong Hee Jin; Kim Woo Joo

doi:10.3346/jkms.2021.36.e245

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자료유형: 학술저널

저자정보: Hyun Hakjun (Division of Infectious Diseases Department of Internal Medicine Korea University College of Medicin) Song Joon Young (Division of Infectious Diseases Department of Internal Medicine Korea University College of Medicin) Seong Hye (Division of Infectious Diseases Department of Internal Medicine Korea University College of Medicin) Yoon Jin Gu (Division of Infectious Diseases Department of Internal Medicine Korea University College of Medicin) Noh Ji Yun (Division of Infectious Diseases Department of Internal Medicine Korea University College of Medicin) Cheong Hee Jin (Division of Infectious Diseases Department of Internal Medicine Korea University College of Medicin) Kim Woo Joo (Division of Infectious Diseases Department of Internal Medicine Korea University College of Medicin)

저널정보: 대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.34

발행연도: 2021.8

수록면: 1 - 5 (5page)

DOI: 10.3346/jkms.2021.36.e245

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Since February 26, 2021, when vaccination against coronavirus disease 2019 (COVID-19) began in South Korea, patients who visited the Korea University Guro Hospital with suspected adverse events after COVID-19 vaccination were monitored actively with interest. We encountered five unusual cases of polyarthralgia and myalgia syndrome in patients who received the ChAdOx1 nCOV-19 (AstraZeneca) vaccine. The patients (median age 67 years) were not previously diagnosed with arthropathy and rheumatologic diseases. They developed fever, myalgia, joint pain, and swelling three to seven days after vaccination. The symptoms persisted for up to 47 days despite antipyretic treatment. Arthralgia occurred in multiple joints, including small and large joints. A whole-body Technetium-99m methylene diphosphonate bone scan revealed unusual uptakes in the affected joints. Non-steroidal anti-inflammatory drugs with or without prednisolone relieved the symptoms of all patients. Further monitoring is required to clarify the long-term prognosis of this syndrome.

#COVID-19 #Vaccine #Safety #Adverse Event #Arthritis

참고문헌 (13)

참고문헌 신청

Song Joon Young / 2021 / Early Safety Monitoring of COVID-19 Vaccines in Healthcare Workers / Journal of Korean Medical Science 36(15):1~4

Atasheva S / 2019 / Innate immunity to adenovirus : lessons from mice / FEBS Lett 593(24):3461~3483

Shimizu K / 2021 / Adenovirus vector-induced IL-6promotes leaky adenoviral gene expression, leading to acute hepatotoxicity / J Immunol 206(2):410~421

Zhang Y / 2001 / Acute cytokine response to systemic adenoviral vectors in mice is mediated by dendritic cells and macrophages / Mol Ther 3(5 Pt 1):697~707

Greinacher A / 2021 / Thrombotic thrombocytopenia after ChAdOx1 nCov-19 vaccination / N Engl J Med 384(22):2092~2101

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