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논문 기본 정보

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학술저널
저자정보
Lee Kyung Ae (Division of Endocrinology and Metabolism Department of Internal Medicine Research Institute of Clin) Jin Heung Yong (Division of Endocrinology and Metabolism Department of Internal Medicine Research Institute of Clin) Kim Yu Ji (Division of Endocrinology and Metabolism Department of Internal Medicine Research Institute of Clin) Im Yong-Jin (Center for Clinical Pharmacology Biochemical Research Institute Jeonbuk National University Hospita) Kim Eun-Young (Center for Clinical Pharmacology Biochemical Research Institute Jeonbuk National University Hospita) Park Tae Sun (Division of Endocrinology and Metabolism Department of Internal Medicine Research Institute of Clin)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.36
발행연도
2021.9
수록면
1 - 11 (11page)
DOI
10.3346/jkms.2021.36.e230

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Background: Real-world data analysis is useful for identifying treatment patterns. Understanding drug prescription patterns of type 2 diabetes mellitus may facilitate diabetes management. We aimed to analyze treatment patterns of type 2 diabetes mellitus using Observational Medical Outcomes Partnership Common Data Model based on electronic health records. Methods: This retrospective, observational study employed electronic health records of patients who visited Jeonbuk National University Hospital in Korea during January 2000? December 2019. Data were transformed into the Observational Medical Outcomes Partnership Common Data Model and analyzed using R version 4.0.3 and ATLAS ver. 2.7.6. Prescription frequency for each anti-diabetic drug, combination therapy pattern, and prescription pattern according to age, renal function, and glycated hemoglobin were analyzed. Results: The number of adults treated for type 2 diabetes mellitus increased from 1,867 (2.0%) in 2000 to 9,972 (5.9%) in 2019. In the early 2000s, sulfonylurea was most commonly prescribed (73%), and in the recent years, metformin has been most commonly prescribed (64%). Prescription rates for DPP4 and SGLT2 inhibitors have increased gradually over the past few years. Monotherapy prescription rates decreased, whereas triple and quadruple combination prescription rates increased steadily. Different drug prescription patterns according to age, renal function, and glycated hemoglobin were observed. The proportion of patients with HbA1c ≤ 7% increased from 31.1% in 2000 to 45.6% in 2019, but that of patients visiting the emergency room for severe hypoglycemia did not change over time. Conclusion: Medication utilization patterns have changed significantly over the past 20 years with an increase in the use of newer drugs and a shift to combination therapies. In addition, various prescription patterns were demonstrated according to the patient characteristics in actual practice. Although glycemic control has improved, the proportion within the target is still low, underscoring the need to improve diabetes management.
#Diabetes Mellitus Type 2 #Hypoglycemic Agents #Common Data Model #Electronic Health Records

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참고문헌 (29)

참고문헌 신청
정찬희 / 2021 / Diabetes Fact Sheets in Korea, 2020: An Appraisal of Current Status / Diabetes and Metabolism Journal 45(1):1~10 Crossref 김보연 / 2019 / Diabetes Fact Sheets in Korea, 2018: An Appraisal of Current Status / Diabetes and Metabolism Journal 43(4):487~494 dbpia White JR Jr / 2014 / A brief history of the development of diabetes medications / Diabetes Spectr 27(2):82~86 google schola Giugliano D / 2020 / Efficacy of SGLT-2inhibitors in older adults with diabetes : systematic review with meta-analysis of cardiovascular outcome trials / Diabetes Res Clin Pract 162:108114 google schola Kristensen SL / 2019 / Cardiovascular, mortality, and kidney outcomes with GLP-1 receptor agonists in patients with type 2 diabetes : a systematic review and meta-analysis of cardiovascular outcome trials / Lancet Diabetes Endocrinol 7(10):776~785 google schola

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