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저자정보
Ryu Byung-Han (Department of Internal Medicine Gyeongsang National University Changwon Hospital Changwon Korea.) Hong Sun In (Department of Internal Medicine Gyeongsang National University Changwon Hospital Changwon Korea.) Lim Su Jin (Department of Internal Medicine Gyeongsangnam-do Masan Medical Center Changwon Korea.) Cho Younghwa (Department of Internal Medicine Korea Labour Welfare Corporation Changwon Hospital Changwon Korea.) Hwang Cheolgu (Department of Internal Medicine Busan Medical Center Busan Korea.) Kang Hyungseok (Department of Chest Medicine Masan National Tuberculosis Hospital Changwon Korea.) Kim Si-Ho (Department of Internal Medicine Samsung Changwon Hospital Sungkyunkwan University School of Medicin) Wi Yu Mi (Department of Internal Medicine Samsung Changwon Hospital Sungkyunkwan University School of Medicin) Hong Kyung-Wook (Department of Internal Medicine Gyeongsang National University Hospital Gyeongsang National Univers) Bae In-Gyu (Department of Internal Medicine Gyeongsang National University Hospital Gyeongsang National Univers) Cho Oh-Hyun (Department of Internal Medicine Gyeongsang National University Changwon Hospital Changwon Korea.Gye)
저널정보
대한의학회 Journal of Korean Medical Science Journal of Korean Medical Science Vol.36 No.49
발행연도
2021.12
수록면
1 - 9 (9page)
DOI
10.3346/jkms.2021.36.e341

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Background: Data on severe acute respiratory syndrome-coronavirus-2 (SARS-CoV-2) delta variant virulence are insufficient. We retrospectively compared the clinical features of adult coronavirus disease 2019 (COVID-19) patients without risk factors for severe COVID-19 who entered residential treatment centers (RTCs) before and after the delta variant outbreak. Methods: We collected medical information from two RTCs in South Korea. On the basis of nationwide delta variant surveillance, we divided the patients into two groups: 1) the delta-minor group (diagnosed from December 2020?June 2021, detection rate < 10%) and 2) the delta-dominant group (diagnosed during August 2021, detection rate > 90%). After propensity-score matching, the incidences of pneumonia, hospital transfer and need for supplemental oxygen were compared between the groups. In addition, risk factors for hospital transfer were analysed. Results: A total of 1,915 patients were included. The incidence of pneumonia (14.6% vs. 9.2%, P = 0.009), all-cause hospital transfer (10.4% vs. 6.3%, P = 0.020) and COVID-19- related hospital transfer (7.5% vs. 4.8%, P = 0.081) were higher in the delta-dominant group than those in the delta-minor group. In the multivariate analysis, the delta-dominant group was an independent risk factor for all-cause (adjusted odds ratio [aOR], 1.91; 95% confidence interval [CI], 1.16?3.13; P = 0.011) and COVID-19-related hospital transfer (aOR, 1.86; 95% CI, 1.04?3.32; P = 0.036). Conclusion: Hospitalization rates were increased in the adult COVID-19 patients during the delta variant nationwide outbreak. Our results showed that the delta variant may be more virulent than previous lineages.
#COVID-19 #Delta Variant #Virulence #Hospitalization #South Korea

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참고문헌 (14)

참고문헌 신청
World Health Organization / Weekly epidemiological update on COVID-19 - 31 August 2021 (edition 55) google schola Korea Disease Control and Prevention Agency / 2021 / Global trends and characteristics of the SARS-CoV-2 Delta variant / Public Health Wkly Rep 14(33):2363~2365 google schola Korea Disease Control and Prevention Agency / 2021 / July 2021 status and characteristics of the COVID-19variant virus outbreak in the Republic of Korea / Public Health Wkly Rep 14(48):3388~3396 google schola Public Health England / SARS-CoV-2 variants of concern and variants under investigation in England:technical briefing 14 google schola Sheikh A / 2021 / SARS-CoV-2 Delta VOC in Scotland: demographics, risk of hospital admission, and vaccine effectiveness / Lancet 397(10293):2461~2462 google schola

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