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논문 기본 정보

자료유형
학술저널
저자정보
Lei Du (No.8 District of Liver Diseases Qingdao No. 6 People’s Hospital Qingdao China) Lina Wang (Clinical Laboratory Qingdao No. 6 People’s Hospital Qingdao China) Hong Yang (Physical Therapy Qingdao No. 6 People’s Hospital Qingdao China) Jianping Duan (Infectious Disease Qingdao No. 6 People’s Hospital Qingdao China) Jianming Lai (Medical College Qingdao University Qingdao China) Wei Wu (No.8 District of Liver Diseases Qingdao No. 6 People’s Hospital Qingdao China) Shaohua Fan (Blood Purification Centre Qingdao No. 6 People’s Hospital Qingdao China.) Xiaoli Zhi (Infectious Disease Qingdao No. 6 People’s Hospital Qingdao China)
저널정보
연세대학교 의과대학 Yonsei Medical Journal Yonsei Medical Journal 제62권 제12호
발행연도
2021.12
수록면
1,073 - 1,082 (10page)
DOI
10.3349/ymj.2021.62.12.1073

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Purpose: The purpose of this study was to investigate the influences of sex comb on midleg like-2 (SCML2) on hepatocellular carcinoma (HCC) and potentially related mechanisms. Materials and Methods: SCML2 expression in tumor tissues and cells was analyzed using the TCGA database and/or qRT-PCR. The proliferation of HCC cells was detected by CCK-8, colony formation, and EdU assays. The migration and invasion of HCC cells were detected by transwell and wound healing assays. Apoptosis of HCC cells was determined by flow cytometry. Additionally, qRT-PCR and Western blot were used to detect the expression of SCML2 and Wnt/β-catenin/epithelial?mesenchymal transition (EMT) signaling. A xenograft model in mice was established to verify the in vitro findings. Results: We found that SCML2 was highly expressed in HCC tissues and cells and that high expression of SCML2 was correlated with poor prognosis in HCC patients. SCML2 overexpression promoted proliferation, invasion, and migration and repressed apoptosis of HCC cells. The reverse results were obtained in SCML2-silenced cells. Further, we found that SCML2 activated the Wnt/β-catenin/EMT pathway. SCML2 silencing reduced the protein levels of Wnt3a, β-catenin, N-cadherin, Vimentin, and Snail and enhanced E-cadherin protein expression both in vivo and in vitro. Conclusion: SCML2 silencing inhibits the proliferation, migration, and invasion of HCC cells by regulating the Wnt/β-catenin/EMT pathway.
#Sex comb on midleg like-2 #hepatocellular carcinoma #proliferation #apoptosis #signaling pathway

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참고문헌 (35)

참고문헌 신청
Torre LA / 2015 / Global cancer statistics, 2012 / CA Cancer J Clin 65:87~108 google schola Kim NG / 2018 / Temporal trends in disease presentation and survival of patients with hepatocellular carcinoma : a real-world experience from 1998 to 2015 / Cancer 124:2588~2598 google schola Fong ZV / 2014 / The clinical management of hepatocellular carcinoma in the United States, Europe, and Asia : a comprehensive and evidence-based comparison and review / Cancer 120:2824~2838 google schola Zhu ZX / 2016 / Treatment strategy for hepatocellular carcinoma in China : radiofrequency ablation versus liver resection / Jpn J Clin Oncol 46:1075~1080 google schola Zhang X / 2018 / Significance of presence of microvascular invasion in specimens obtained after surgical treatment of hepatocellular carcinoma / J Gastroenterol Hepatol 33:347~354 google schola

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