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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 454 - 464 (11page)
- DOI
- 10.5125/jkaoms.2021.47.6.454
이용수
초록· 키워드
오류제보하기
Objectives: This study aimed to investigate the in vitro osteoinductivity of the combination of bone morphogenetic protein-2 (BMP-2) and nano-hydroxyapatite (nHAp) and the in vivo effects of implants coated with nHAp/BMP-2.
Materials and Methods: To evaluate the in vitro efficacy of nHAp/BMP-2 on bone formation, bone marrow-derived mesenchymal stem cells (BM-MSCs) were seeded onto titanium disks coated with collagen (Col), Col/nHAp, or Col/nHAp/BMP-2. Protein levels were determined by a biochemical assay and reverse transcriptase-polymerase chain reaction. Stem cell differentiation was analyzed by flow cytometry. For in vivo studies with mice, Col, Col/nHAp, and Col/nHAp/BMP-2 were injected in subcutaneous pockets. Titanium implants or implants coated with Col/nHAp/BMP-2 were placed bilaterally on rabbit tibias and evaluated for 4 weeks.
Results: In the in vitro study, BM-MSCs on Col/nHAp/BMP-2 showed reduced levels of CD73, CD90, and CD105 and increased levels of glycos-aminoglycan, osteopontin, and alkaline phosphatase activity. After 4 weeks, the Col/nHAp/BMP-2 implant showed greater bone formation than the control (P=0.07), while no differences were observed in bone implant contact and removal torque.
Conclusion: These results suggest that a combination of BMP-2 and an nHAp carrier would activate osseointegration on dental implant surfaces.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Sachin Mamidwar / 2009 / Basic research methods and current trends of dental implant surfaces / Journal of Biomedical Materials Research Part B: Applied Biomaterials 88B(2):579~596
David M. Dohan Ehrenfest / 2010 / Classification of osseointegrated implant surfaces: materials, chemistry and topography / Trends in Biotechnology 28(4):198~206
Gustavo Mendonça / 2008 / Advancing dental implant surface technology – From micron- to nanotopography / Biomaterials 29(28):3822~3835
Sascha A. Jovanovic / 2003 / Long-term functional loading of dental implants in rhBMP-2 induced bone / Clinical Oral Implants Research 14(6):793~803
J-C. Park / 2012 / Dose- and time-dependent effects of recombinant human bone morphogenetic protein-2 on the osteogenic and adipogenic potentials of alveolar bone-derived stromal cells / Journal of Periodontal Research 47(5):645~654
David M. Dohan Ehrenfest / 2010 / Classification of osseointegrated implant surfaces: materials, chemistry and topography / Trends in Biotechnology 28(4):198~206
Gustavo Mendonça / 2008 / Advancing dental implant surface technology – From micron- to nanotopography / Biomaterials 29(28):3822~3835
Sascha A. Jovanovic / 2003 / Long-term functional loading of dental implants in rhBMP-2 induced bone / Clinical Oral Implants Research 14(6):793~803
J-C. Park / 2012 / Dose- and time-dependent effects of recombinant human bone morphogenetic protein-2 on the osteogenic and adipogenic potentials of alveolar bone-derived stromal cells / Journal of Periodontal Research 47(5):645~654
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