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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.10
- 수록면
- 390 - 399 (10page)
- DOI
- https://doi.org/10.3904/kjm.2021.96.5.390
이용수
초록· 키워드
오류제보하기
The most important thing for the management of drug susceptible pulmonary tuberculosis is to diagnose active pulmonary tuberculosis as soon as possible and prevent the occurrence of new patients through appropriate treatment. Therefore, it should be a priority to quickly detect tuberculosis mycobacterium and quickly exclude drug-resistant tuberculosis before treatment begins. To this end, recent guidelines recommend the general use of Mycobacterium tuberculosis (MTB) polymerase chain reaction (PCR) tests, Xpert MTB/RIF tests, and rapid sensitivity tests through line probe assay (LPA). In addition, if the results of the test are positive, it is important to establish an in-hospital reporting system so that rapid reporting can be made. The treatment principle for drug susceptible pulmonary tuberculosis is 2 months of initial intensive phase (isoniazid, rifampin, ethambutol, pyrazinamide) followed by 4 months of maintenance phase (isoniazid, rifampin). Despite global efforts to shorten the duration of the treatment, the treatment of drug susceptible pulmonary tuberculosis has not changed for more than 35 years, and problems such as increased side effects and reduced drug adherence are serious obstacles to tuberculosis management. Therefore, efforts have been steadily made to shorten the treatment period through the combination of new drugs worldwide, and after many failures, they are finally paying off. A recently published Study 31/A5349 study found that 4 months short-term regimen using rifapentine (RPT) and moxifloxacin (MFX) demonstrated non-inferiority in existing standard regimen, as the result, a revision of World Health Organization guidelines is scheduled that 4 months short-term regimen using RPT and MFX may be an alternative. However, it is unlikely that RPT/MFX 4 months short-term regimen will be applied immediately in Korea because the use of RPT is currently limited in Korea due to the high frequency of side effects.
목차
등록된 정보가 없습니다.
참고문헌 (40)
참고문헌 신청
Diagnostic standards and classification of tuberculosis in adults and children / 2000 / This official statement of the American Thoracic Society and the Centers for Disease Control and Prevention was adopted by the ATS Board of Directors, July 1999. This statement was endorsed by the Council of the Infectious Disease Society of America, September 1999 / Am J Respir Crit Care Med 161:1376~1395
Park YS / 2010 / Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea / Int J Tuberc Lung Dis 14:1069~1071
Kanchana MV / 2000 / Evaluation of the BACTEC MGIT 960 system for the recovery of mycobacteria / Diagn Microbiol Infect Dis 37:31~36
Centers for Disease Control and Prevention (CDC). / 2009 / Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis / MMWR Morb Mortal Wkly Rep 58:7~10
MacLean E / 2020 / Advances in molecular diagnosis of tuberculosis / J Clin Microbiol. 58:e01582
Park YS / 2010 / Rapid increase of non-tuberculous mycobacterial lung diseases at a tertiary referral hospital in South Korea / Int J Tuberc Lung Dis 14:1069~1071
Kanchana MV / 2000 / Evaluation of the BACTEC MGIT 960 system for the recovery of mycobacteria / Diagn Microbiol Infect Dis 37:31~36
Centers for Disease Control and Prevention (CDC). / 2009 / Updated guidelines for the use of nucleic acid amplification tests in the diagnosis of tuberculosis / MMWR Morb Mortal Wkly Rep 58:7~10
MacLean E / 2020 / Advances in molecular diagnosis of tuberculosis / J Clin Microbiol. 58:e01582
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