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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제2호
- 발행연도
- 2017.3
- 수록면
- 145 - 152 (8page)
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초록· 키워드
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Remote ischemic preconditioning (RIPC) is an intrinsic phenomenon whereby 3~4 consecutive ischemia-reperfusion cycles to a remote tissue (noncardiac) increases the tolerance of the myocardium to sustained ischemiareperfusion induced injury. Remote ischemic preconditioning induces the local release of chemical mediators which activate the sensory nerve endings to convey signals to the brain. The latter consequently stimulates the efferent nerve endings innervating the myocardium to induce cardioprotection. Indeed, RIPC-induced cardioprotective effects are reliant on the presence of intact neuronal pathways, which has been confirmed using nerve resection of nerves including femoral nerve, vagus nerve, and sciatic nerve. The involvement of neurogenic signaling has been further substantiated using various pharmacological modulators including hexamethonium and trimetaphan. The present review focuses on the potential involvement of neurogenic pathways in mediating remote ischemic preconditioninginduced cardioprotection.
목차
등록된 정보가 없습니다.
참고문헌 (45)
참고문헌 신청
Alhejily W / 2014 / The effect of ischemia-reperfusion injury on measures of vascular function / Clin Hemorheol Microcirc 56:265~271
Randhawa PK / 2015 / RIPC for multiorgan salvage in clinical settings : evolution of concept, evidences and mechanisms / Eur J Pharmacol 746:317~332
Przyklenk K / 1993 / Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion / Circulation 87:893~899
Kant R / 2008 / Remote renal preconditioning-induced cardioprotection : a key role of hypoxia inducible factor-prolyl 4-hydroxylases / Mol Cell Biochem 312:25~31
Wang Y / 2001 / Intestinal ischemia induces late preconditioning against myocardial infarction : a role for inducible nitric oxide synthase / Cardiovasc Res 49:391~398
Randhawa PK / 2015 / RIPC for multiorgan salvage in clinical settings : evolution of concept, evidences and mechanisms / Eur J Pharmacol 746:317~332
Przyklenk K / 1993 / Regional ischemic 'preconditioning' protects remote virgin myocardium from subsequent sustained coronary occlusion / Circulation 87:893~899
Kant R / 2008 / Remote renal preconditioning-induced cardioprotection : a key role of hypoxia inducible factor-prolyl 4-hydroxylases / Mol Cell Biochem 312:25~31
Wang Y / 2001 / Intestinal ischemia induces late preconditioning against myocardial infarction : a role for inducible nitric oxide synthase / Cardiovasc Res 49:391~398
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