지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제5호
- 발행연도
- 2018.9
- 수록면
- 467 - 479 (13page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.5.467
이용수
초록· 키워드
오류제보하기
The aging process induces a plethora of changes in the body including alterations in hormonal regulation and metabolism in various organs including the heart. Aging is associated with marked increase in the vulnerability of the heart to ischemia-reperfusion injury. Furthermore, it significantly hampers the development of adaptive response to various forms of conditioning stimuli (pre/post/remote conditioning).
Aging significantly impairs the activation of signaling pathways that mediate preconditioning-induced cardioprotection. It possibly impairs the uptake and release of adenosine, decreases the number of adenosine transporter sites and down-regulates the transcription of adenosine receptors in the myocardium to attenuate adenosine- mediated cardioprotection. Furthermore, aging decreases the expression of peroxisome proliferator-activated receptor gamma co-activator 1-alpha (PGC-1α) and subsequent transcription of catalase enzyme which subsequently increases the oxidative stress and decreases the responsiveness to preconditioning stimuli in the senescent diabetic hearts. In addition, in the aged rat hearts, the conditioning stimulus fails to phosphorylate Akt kinase that is required for mediating cardioprotective signaling in the heart. Moreover, aging increases the concentration of Na+ and K+, connexin expression and caveolin abundance in the myocardium and increases the susceptibility to ischemia-reperfusion injury. In addition, aging also reduces the responsiveness to conditioning stimuli possibly due to reduced kinase signaling and reduced STAT-3 phosphorylation. However, aging is associated with an increase in MKP-1 phosphorylation, which dephosphorylates (deactivates) mitogen activated protein kinase that is involved in cardioprotective signaling. The present review describes aging as one of the major confounding factors in attenuating remote ischemic preconditioninginduced cardioprotection along with the possible mechanisms.
목차
등록된 정보가 없습니다.
참고문헌 (106)
참고문헌 신청
Randhawa PK / 2015 / RIPC for multiorgan salvage in clinical settings: evolution of concept, evidences and mechanisms / Eur J Pharmacol 746:317~332
Randhawa PK / 2016 / Unraveling the role of adenosine in remote ischemic preconditioning-induced cardioprotection / Life Sci 155:140~146
Murry CE / 1986 / Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium / Circulation 74:1124~1136
Vinten-Johansen J / 2011 / Perconditioning and postconditioning: current knowledge, knowledge gaps, barriers to adoption, and future directions / J Cardiovasc Pharmacol Ther 16:260~266
Randhawa PK / 2016 / Gadolinium and ruthenium red attenuate remote hind limb preconditioning-induced cardioprotection: possible role of TRP and especially TRPV channels / Naunyn Schmiedebergs Arch Pharmacol 389:887~896
Randhawa PK / 2016 / Unraveling the role of adenosine in remote ischemic preconditioning-induced cardioprotection / Life Sci 155:140~146
Murry CE / 1986 / Preconditioning with ischemia: a delay of lethal cell injury in ischemic myocardium / Circulation 74:1124~1136
Vinten-Johansen J / 2011 / Perconditioning and postconditioning: current knowledge, knowledge gaps, barriers to adoption, and future directions / J Cardiovasc Pharmacol Ther 16:260~266
Randhawa PK / 2016 / Gadolinium and ruthenium red attenuate remote hind limb preconditioning-induced cardioprotection: possible role of TRP and especially TRPV channels / Naunyn Schmiedebergs Arch Pharmacol 389:887~896
함께 읽어보면 좋을 논문
논문 유사도에 따라 DBpia 가 추천하는 논문입니다. 함께 보면 좋을 연관 논문을 확인해보세요!
-
Mechanisms involved in adenosine pharmacological preconditioning-induced cardioprotection
The Korean Journal of Physiology & Pharmacology
2018 .05
-
Neurogenic pathways in remote ischemic preconditioning induced cardioprotection: Evidences and possible mechanisms
The Korean Journal of Physiology & Pharmacology
2017 .03
-
Phosphorylation in Novel Mitochondrial Creatine Kinase Tyrosine Residues Render Cardioprotection against Hypoxia/Reoxygenation Injury
지질·동맥경화학회지
2021 .01
-
Mitochondrial Metabolic Inhibition and Cardioprotection
Korean Circulation Journal
2017 .01
-
Pharmacological Approaches to Limit Ischemic and Reperfusion Injuries of the Heart: Analysis of Experimental and Clinical Data on P2Y12 Receptor Antagonists
Korean Circulation Journal
2022 .10
-
Anesthetic-induced myocardial protection in cardiac surgery: relevant mechanisms and clinical translation
Anesthesia and Pain Medicine
2018 .01
-
Neuroprotective potential of imatinib in global ischemiareperfusion- induced cerebral injury: possible role of Janus-activated kinase 2/signal transducer and activator of transcription 3 and connexin 43
The Korean Journal of Physiology & Pharmacology
2020 .01
-
Adenosine Blockage in Tumor Microenvironment and Improvement of Cancer Immunotherapy
Immune Network
2019 .08
-
Gypenoside XVII protects against myocardial ischemia and reperfusion injury by inhibiting ER stresseinduced mitochondrial injury
Journal of Ginseng Research
2021 .11
-
The Regulation of p27Kip-1 and Bcl2 Expression Is Involved in the Decrease of Osteoclast Proliferation by A2B Adenosine Receptor Stimulation
대한의생명과학회지
2017 .12
-
Hydrogen sulfide restores cardioprotective effects of remote ischemic preconditioning in aged rats via HIF-1?/Nrf2 signaling pathway
The Korean Journal of Physiology & Pharmacology
2021 .01
-
Mangiferin ameliorates cardiac fibrosis in D-galactose-induced aging rats by inhibiting TGF-?/p38/MK2 signaling pathway
The Korean Journal of Physiology & Pharmacology
2021 .01
-
Modulation of Inula racemosa Hook Extract on Cardioprotection by Ischemic Preconditioning in Hyperlipidaemic Rats
Journal of Pharmacopuncture
2022 .12
-
Hepatic ischemia-reperfusion injury with respect to oxidative stress and inflammatory response: a narrative review
Journal of Yeungnam Medical Science
2023 .04
-
Voluntary Wheel Running Exercise Improves Aging-Induced Sarcopenia via Activation of Peroxisome Proliferator-Activated Receptor Gamma Coactivator-1α/Fibronectin Type III Domain- Containing Protein 5/Adenosine Monophosphate-Activated Protein Kinase Signaling Pathway
International Neurourology Journal
2021 .01
-
Role of 5´-AMP-Activated Protein Kinase Activators in Regulating Nuclear Factor Kappa B Signaling
International Neurourology Journal
2016 .01
-
신장 이식과 허혈 조건화: 과거, 현재, 미래
Anesthesia and Pain Medicine
2018 .01
-
Paeoniflorin treatment regulates TLR4/NF-?B signaling, reduces cerebral oxidative stress and improves white matter integrity in neonatal hypoxic brain injury
The Korean Journal of Physiology & Pharmacology
2021 .01
-
응급실에 내원한 발작심실상성빈맥 환자에서 투약 방법 교육에 따른 아데노신의 효과
대한응급의학회지
2015 .01
-
Cardiac Magnetic Resonance in the Aging Heart
Journal of Cardiovascular Imaging
2022 .07
이 논문의 저자 정보
최근 본 자료
댓글(0)
0