지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제21권 제6호
- 발행연도
- 2017.11
- 수록면
- 643 - 650 (8page)
이용수
초록· 키워드
오류제보하기
Vascular dementia (VaD) is a group of heterogeneous diseases with the common feature of cerebral hypoperfusion. To identify key factors contributing to VaD pathophysiology, we performed a detailed comparison of Wistar and Sprague? Dawley (SD) rats subjected to permanent bilateral common carotid artery occlusion (BCCAo). Eight-week old male Wistar and SD rats underwent BCCAo, followed by a reference memory test using a five-radial arm maze with tactile cues. Continuous monitoring of cerebral blood flow (CBF) was performed with a laser Doppler perfusion imaging (LDPI) system. A separate cohort of animals was sacrificed for evaluation of the brain vasculature and white matter damage after BCCAo. We found reference memory impairment in Wistar rats, but not in SD rats. Moreover, our LDPI system revealed that Wistar rats had significant hypoperfusion in the brain region supplied by the posterior cerebral artery (PCA). Furthermore, Wistar rats showed more profound CBF reduction in the forebrain region than did SD rats. Post-mortem analysis of brain vasculature demonstrated greater PCA plasticity at all time points after BCCAo in Wistar rats. Finally, we confirmed white matter rarefaction that was only observed in Wistar rats. Our studies show a comprehensive and dynamic CBF status after BCCAo in Wistar rats in addition to severe PCA dolichoectasia, which correlated well with white matter lesion and memory decline.
목차
등록된 정보가 없습니다.
참고문헌 (31)
참고문헌 신청
Plassman BL / 2007 / Prevalence of dementia in the United States : the aging, demographics, and memory study / Neuroepidemiology 29:125~132
Sopala M / 2001 / Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory / J Neural Transm(Vienna) 108:1445~1456
Venkat P / 2015 / Models and mechanisms of vascular dementia / Exp Neurol 272:97~108
Román GC / 2004 / Vascular cognitive disorder : a new diagnostic category updating vascular cognitive impairment and vascular dementia / J Neurol Sci 226:81~87
Cho KO / 2006 / Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion / J Neurosci Res 83:285~291
Sopala M / 2001 / Chronic cerebral hypoperfusion in the rat enhances age-related deficits in spatial memory / J Neural Transm(Vienna) 108:1445~1456
Venkat P / 2015 / Models and mechanisms of vascular dementia / Exp Neurol 272:97~108
Román GC / 2004 / Vascular cognitive disorder : a new diagnostic category updating vascular cognitive impairment and vascular dementia / J Neurol Sci 226:81~87
Cho KO / 2006 / Minocycline attenuates white matter damage in a rat model of chronic cerebral hypoperfusion / J Neurosci Res 83:285~291
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