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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제1호
- 발행연도
- 2018.1
- 수록면
- 81 - 89 (9page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.1.81
이용수
초록· 키워드
오류제보하기
This study evaluated the anti-asthmatic activities of 2,6-di-tert-butyl-4-hydroxymethylphenol (DBHP) that is a potent phenolic antioxidant in edible vegetable oil. The effects of DBHP on bronchial asthma were evaluated by determining the specific airway resistance (sRaw) and tidal volume (TV) during the immediate asthmatic response (IAR) and the late-phase asthmatic response (LAR) in guinea pigs with aerosolized ovalbumin-induced asthma. Recruitment of leukocytes and the levels of biochemical inflammatory mediators were determined in the bronchoalveolar lavage fluids (BALFs), and histopathological surveys performed in lung tissues. DBHP significantly inhibited the increased sRaw and improved the decreased TV on IAR and LAR, and also inhibited recruitment of eosinophils and neutrophils into the lung, and release of biochemical inflammatory mediators such as histamine and phospholipase A2 from these infiltrated leukocytes, and improved pathological changes. However, anti-asthmatic activities of DBHP at oral doses of 12.5 to 50 mg/kg was less than those of dexamethasone (5 mg/kg, p.o.) and cromoglycate (10 mg/kg, p.o.), but more potent or similar to that of salbutamol (5 mg/kg, p.o.). These results in the present study suggest that anti-asthmatic effects of DBHP in the guinea pigs model of OVAinduced asthmatic responses principally are mediated by inhibiting the recruitments of the leukocytes and the release of biochemical inflammatory mediators from these infiltrated leukocytes.
목차
등록된 정보가 없습니다.
참고문헌 (39)
참고문헌 신청
Leick EA / 2012 / Effects of repeated stress on distal airway inflammation, remodeling and mechanics in an animal model of chronic airway inflammation / Neuroimmunomodulation 19:1~9
형경은 / 2017 / Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response / The Korean Journal of Physiology & Pharmacology 21(3):335~343
Matsumoto T / 1994 / Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig / J Pharmacol Exp Ther 269:1236~1244
Sanjar S / 1990 / Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of antiasthma drugs / Br J Pharmacol 99:679~686
Hanania NA / 2008 / Targeting airway inflammation in asthma: current and future therapies / Chest 133:989~998
형경은 / 2017 / Therapeutic effects of orally administered CJLP55 for atopic dermatitis via the regulation of immune response / The Korean Journal of Physiology & Pharmacology 21(3):335~343
Matsumoto T / 1994 / Pharmacological modulation of immediate and late airway response and leukocyte infiltration in the guinea pig / J Pharmacol Exp Ther 269:1236~1244
Sanjar S / 1990 / Antigen challenge induces pulmonary airway eosinophil accumulation and airway hyperreactivity in sensitized guinea-pigs: the effect of antiasthma drugs / Br J Pharmacol 99:679~686
Hanania NA / 2008 / Targeting airway inflammation in asthma: current and future therapies / Chest 133:989~998
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