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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제3호
- 발행연도
- 2018.5
- 수록면
- 301 - 309 (9page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.3.301
이용수
초록· 키워드
오류제보하기
Statins mediate vascular protection and reduce the prevalence of cardiovascular diseases. Recent work indicates that statins have anticonvulsive effects in the brain; however, little is known about the precise mechanism for its protective effect in kainic acid (KA)-induced seizures. Here, we investigated the protective effects of atorvastatin pretreatment on KA-induced neuroinflammation and hippocampal cell death. Mice were treated via intragastric administration of atorvastatin for 7 days, injected with KA, and then sacrificed after 24 h. We observed that atorvastatin pretreatment reduced KA-induced seizure activity, hippocampal cell death, and neuroinflammation. Atorvastatin pretreatment also inhibited KA-induced lipocalin-2 expression in the hippocampus and attenuated KA-induced hippocampal cyclooxygenase- 2 expression and glial activation. Moreover, AKT phosphorylation in KA-treated hippocampus was inhibited by atorvastatin pretreatment. These findings suggest that atorvastatin pretreatment may protect hippocampal neurons during seizures by controlling lipocalin-2-associated neuroinflammation.
목차
등록된 정보가 없습니다.
참고문헌 (43)
참고문헌 신청
McCord MC / 2008 / Effect of age on kainate-induced seizure severity and cell death / Neuroscience 154:1143~1153
Carta M / 2014 / Kainate receptors in the hippocampus / Eur J Neurosci 39:1835~1844
Ravizza T / 2005 / Inflammatory response and glia activation in developing rat hippocampus after status epilepticus / Epilepsia 46(Suppl 5):113~117
Kim JE / 2012 / Tumor necrosis factor-${\alpha}$ -mediated threonine 435 phosphorylation of p65 nuclear factor-${\kappa}B$ subunit in endothelial cells induces vasogenic edema and neutrophil infiltration in the rat piriform cortex following status epilepticus / J Neuroinflammation 9:6
Shin HJ / 2012 / Effect of the calcineurin inhibitor FK506 on $K^{+}-Cl^{-}$ cotransporter 2 expression in the mouse hippocampus after kainic acid-induced status epilepticus / J Neural Transm (Vienna) 119:669~677
Carta M / 2014 / Kainate receptors in the hippocampus / Eur J Neurosci 39:1835~1844
Ravizza T / 2005 / Inflammatory response and glia activation in developing rat hippocampus after status epilepticus / Epilepsia 46(Suppl 5):113~117
Kim JE / 2012 / Tumor necrosis factor-
Shin HJ / 2012 / Effect of the calcineurin inhibitor FK506 on
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