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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제1호
- 발행연도
- 2018.1
- 수록면
- 63 - 70 (8page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.1.63
이용수
초록· 키워드
오류제보하기
Cilostazol is a selective inhibitor of type 3 phosphodiesterase (PDE3) and has been widely used as an antiplatelet agent. Cilostazol mediates this activity through effects on the cyclic adenosine monophosphate (cAMP) signaling cascade.
Recently, it has attracted attention as a neuroprotective agent. However, little is known about cilostazol’s effect on excitotoxicity induced neuronal cell death. Therefore, this study evaluated the neuroprotective effect of cilostazol treatment against hippocampal neuronal damage in a mouse model of kainic acid (KA)-induced neuronal loss. Cilostazol pretreatment reduced KA-induced seizure scores and hippocampal neuron death. In addition, cilostazol pretreatment increased cAMP response element-binding protein (CREB) phosphorylation and decreased neuroinflammation.
These observations suggest that cilostazol may have beneficial therapeutic effects on seizure activity and other neurological diseases associated with excitotoxicity.
목차
등록된 정보가 없습니다.
참고문헌 (34)
참고문헌 신청
Kimura Y / 1985 / Effect of cilostazol on platelet aggregation and experimental thrombosis / Arzneimittelforschung 35:1144~1149
Kambayashi J / 2003 / Cilostazol as a unique antithrombotic agent / Curr Pharm Des 9:2289~2302
Miyamoto N / 2010 / Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain / J Cereb Blood Flow Metab 30:299~310
Lee JH / 2006 / Neuroprotection by cilostazol, a phosphodiesterase type 3 inhibitor, against apoptotic white matter changes in rat after chronic cerebral hypoperfusion / Brain Res 1082:182~191
Qi DS / 2016 / Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1 / Brain Res 1653:67~74
Kambayashi J / 2003 / Cilostazol as a unique antithrombotic agent / Curr Pharm Des 9:2289~2302
Miyamoto N / 2010 / Phosphodiesterase III inhibition promotes differentiation and survival of oligodendrocyte progenitors and enhances regeneration of ischemic white matter lesions in the adult mammalian brain / J Cereb Blood Flow Metab 30:299~310
Lee JH / 2006 / Neuroprotection by cilostazol, a phosphodiesterase type 3 inhibitor, against apoptotic white matter changes in rat after chronic cerebral hypoperfusion / Brain Res 1082:182~191
Qi DS / 2016 / Neuroprotection of Cilostazol against ischemia/reperfusion-induced cognitive deficits through inhibiting JNK3/caspase-3 by enhancing Akt1 / Brain Res 1653:67~74
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