지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한약리학회 The Korean Journal of Physiology & Pharmacology The Korean Journal of Physiology & Pharmacology 제22권 제4호
- 발행연도
- 2018.7
- 수록면
- 427 - 436 (10page)
- DOI
- https://doi.org/10.4196/kjpp.2018.22.4.427
이용수
초록· 키워드
오류제보하기
The objective of this study was to analyze the concurrent treatment effects of ursolic acid (UA) and low-intensity treadmill exercise and to confirm the effectiveness of UA as an exercise mimetic to safely improve muscle atrophy?related diseases using Sprague-Dawley (SD) rats with skeletal muscle atrophy. Significant muscle atrophy was induced in male SD rats through hind limb immobilization using casting for 10 days. The muscle atrophy?induced SD rats were group into four: SED, sedentary; UA, daily intraperitoneal UA injection, 5 mg/kg; EX, low-intensity (10-12 m/min, 0° grade) treadmill exercise; and UEX, daily intraperitoneal UA injection, 5 mg/kg, and low-intensity (10-12 m/min, 0° grade) treadmill exercise. After 8 weeks of treatment, endurance capacity was analyzed using a treadmill, and tissues were extracted for analysis of visceral fat mass, body weight, muscle mass, expression of muscle atrophy- and hypertrophy-related genes, and endurance capacity. Although the effects of body weight gain control, muscle mass increase, and endurance capacity improvement were inadequate in the UA group, significant results were confirmed in the UEX group. The UEX group had significantly reduced body weight and visceral fat, significantly improved mass of tibialis anterior and gastrocnemius muscles, and significantly decreased atrophy-related gene expression of MuRF1 and atrogin-1 , but did not have significant change in hypertrophy-related gene expression of Akt and mTOR. The endurance capacity was significantly improved in the EX and UEX groups.
These data suggest that concurrent treatment with low-intensity exercise and UA is effective for atrophy-related physical dysfunctions.
목차
등록된 정보가 없습니다.
참고문헌 (68)
참고문헌 신청
Ebert SM / 2015 / Identification and small molecule inhibition of an activating transcription factor 4 (ATF4)-dependent pathway to age-related skeletal muscle weakness and atrophy / J Biol Chem 290:25497~25511
Tanaka H / 1997 / Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women / J Appl Physiol (1985) 83:1947~1953
Feng HZ / 2011 / Improved fatigue resistance in Gsa-deficient and aging mouse skeletal muscles due to adaptive increases in slow fibers / J Appl Physiol (1985) 111:834~843
Wilson JR / 1993 / Exertional fatigue due to skeletal muscle dysfunction in patients with heart failure / Circulation 87:470~475
Elkin SL / 2000 / Relationship of skeletal muscle mass, muscle strength and bone mineral density in adults with cystic fibrosis / Clin Sci (Lond) 99:309~314
Tanaka H / 1997 / Greater rate of decline in maximal aerobic capacity with age in physically active vs. sedentary healthy women / J Appl Physiol (1985) 83:1947~1953
Feng HZ / 2011 / Improved fatigue resistance in Gsa-deficient and aging mouse skeletal muscles due to adaptive increases in slow fibers / J Appl Physiol (1985) 111:834~843
Wilson JR / 1993 / Exertional fatigue due to skeletal muscle dysfunction in patients with heart failure / Circulation 87:470~475
Elkin SL / 2000 / Relationship of skeletal muscle mass, muscle strength and bone mineral density in adults with cystic fibrosis / Clin Sci (Lond) 99:309~314
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