지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.7
- 수록면
- 824 - 833 (10page)
이용수
초록· 키워드
오류제보하기
Purpose While curative resection is the only chance of cure in pancreatic cancer, controversies exist about the impact of surgical margin status on survival. Non-standardized pathologic report and different criteria on the R1 status made it difficult to implicate adjuvant therapy after resection based on the margin status. We evaluated the influence of resection margins on survival by meta-analysis.
Materials and Methods We thoroughly searched electronic databases of PubMed, EMBASE, and Cochrane Library.
We included studies reporting survival outcomes with different margin status: involved margin (R0 mm), margin clearance with # 1 mm (R0-1 mm), and margin with > 1 mm (R>1 mm).
Hazard ratio (HR) for overall survival was extracted, and a random-effects model was used for pooled analysis.
Results A total of eight retrospective studies involving 1,932 patients were included. Pooled HR for overall survival showed that patients with R>1 mm had reduced risk of death than those with R0-1 mm (HR, 0.74; 95% confidence interval [CI], 0.61 to 0.88; p=0.001). In addition, patients with R0-1 mm had reduced risk of death than those with R0 mm (HR, 0.81; 95% CI, 0.72 to 0.91; p < 0.001). There was no heterogeneity between the included studies (I2 index, 42% and 0%; p=0.10 and p=0.82, respectively).
Conclusion Our results suggest that stratification of the patients based on margin status is warranted in the clinical trials assessing the role of adjuvant treatment for pancreatic cancer.
목차
등록된 정보가 없습니다.
참고문헌 (42)
참고문헌 신청
Siegel R / 2014 / Cancer statistics, 2014 / CA Cancer J Clin 64:9~29
Bilimoria KY / 2007 / National failure to operate on early stage pancreatic cancer / Ann Surg 246:173~180
Neoptolemos JP / 2001 / Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomized controlled trial / Ann Surg 234:758~768
Menon KV / 2009 / Impact of margin status on survival following pancreatoduodenectomy for cancer : the Leeds Pathology Protocol(LEEPP) / HPB(Oxford) 11:18~24
Hartwig W / 2011 / Pancreatic cancer surgery in the new millennium : better prediction of outcome / Ann Surg 254:311~319
Bilimoria KY / 2007 / National failure to operate on early stage pancreatic cancer / Ann Surg 246:173~180
Neoptolemos JP / 2001 / Influence of resection margins on survival for patients with pancreatic cancer treated by adjuvant chemoradiation and/or chemotherapy in the ESPAC-1 randomized controlled trial / Ann Surg 234:758~768
Menon KV / 2009 / Impact of margin status on survival following pancreatoduodenectomy for cancer : the Leeds Pathology Protocol(LEEPP) / HPB(Oxford) 11:18~24
Hartwig W / 2011 / Pancreatic cancer surgery in the new millennium : better prediction of outcome / Ann Surg 254:311~319
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