지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2018.1
- 수록면
- 506 - 517 (12page)
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초록· 키워드
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Purpose This study was conducted to validate the prognostic influence of treatment response among patients with positive circumferential resection margin for locally advanced rectal cancer. Materials and Methods Clinical data of 197 patients with positive circumferential resection margin defined as 2 mm after preoperative chemoradiotherapy followed by total mesorectal excision between 2004 and 2009 were collected for this multicenter validation study. All patients underwent median 50.4 Gy radiation with concurrent fluoropyrimidine based chemotherapy. Treatment response was dichotomized to good response, including treatment response of grade 2 or 3, and poor response, including grade 0 or 1. Results After 52 months median follow-up, 5-year overall survival (OS) for good responders and poor responders was 79.1% and 48.4%, respectively (p < 0.001). In multivariate analysis, circumferential resection margin involvement and treatment response were a prognosticator for OS and locoregional recurrence-free survival. In subgroup analysis, good responders with close margin showed significantly better survival outcomes for survival. Good responders with involved margin and poor responders with close margin shared similar results, whereas poor responders with involved margin had worst survival (5-year OS, 81.2%, 57.0%, 50.0%, and 32.4%, respectively; p < 0.001). Conclusion Among patients with positive circumferential resection margin after preoperative chemoradiotherapy, survival of the good responders was significantly better than poor responders. Subgroup analysis revealed that definition of positive circumferential resection margin may be individualized as involvement for good responders, whereas 2 mm for poor responders.
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등록된 정보가 없습니다.
참고문헌 (22)
참고문헌 신청
Adam IJ / 1994 / Role of circumferential margin involvement in the local recurrence of rectal cancer / Lancet 344:707~711
Quirke P / 1986 / Local recurrence of rectal adenocarcinoma due to inadequate surgical resection: histopathological study of lateral tumour spread and surgical excision / Lancet 2:996~999
Nagtegaal ID / 2002 / Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit / Am J Surg Pathol 26:350~357
Trakarnsanga A / 2013 / What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy? / Ann Surg Oncol 20:1179~1184
Wibe A / 2002 / Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer / Br J Surg 89:327~334
Quirke P / 1986 / Local recurrence of rectal adenocarcinoma due to inadequate surgical resection: histopathological study of lateral tumour spread and surgical excision / Lancet 2:996~999
Nagtegaal ID / 2002 / Circumferential margin involvement is still an important predictor of local recurrence in rectal carcinoma: not one millimeter but two millimeters is the limit / Am J Surg Pathol 26:350~357
Trakarnsanga A / 2013 / What is the significance of the circumferential margin in locally advanced rectal cancer after neoadjuvant chemoradiotherapy? / Ann Surg Oncol 20:1179~1184
Wibe A / 2002 / Prognostic significance of the circumferential resection margin following total mesorectal excision for rectal cancer / Br J Surg 89:327~334
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