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학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
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연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 저널정보
- 대한소아소화기영양학회 Pediatric Gastroenterology, Hepatology & Nutrition Pediatric Gastroenterology, Hepatology & Nutrition 제24권 제5호
- 발행연도
- 2021.9
- 수록면
- 443 - 454 (12page)
- DOI
- 10.5223/pghn.2021.24.5.443
이용수
초록· 키워드
오류제보하기
Purpose: Due to the increasing prevalence of obesity worldwide, non-alcoholic fatty liver disease (NAFLD) has reached epidemic dimensions over time. NAFLD is the most common cause of childhood chronic liver disease. There is a relationship between NAFLD and oxidative stress. This study aims to investigate the changes in thiol/disulfide homeostasis parameters to determine the oxidant/antioxidant balance in obese rats with diet-induced NAFLD and healthy rats.
Methods: Twelve Wistar albino rats were used in this study. Experimentally produced NAFLD obese rats (n=6) and healthy rats were compared. Experimental NAFLD model was created with a special fatty liver diet (Altromin® C1063, Fatty Liver Diet, Exclusivet, Lage, Germany). The biochemical and histopathological features of the groups, as well as serum thiol/disulfide homeostasis parameters, were analyzed and compared.
Results: In the experimentally induced NAFLD rat model, they gained more weight than the control group. Steatosis (at least grade 2) occurred in all rats fed with special fatty liver diet for 12 weeks. Histopathologically, no high-grade inflammation was observed in rats with experimental NAFLD after feeding a diet for 12 weeks. Results revealed that aspartate transaminase and alanine transaminase levels were high, albumin levels were low, oxidant stress parameters increased, and antioxidant thiol groups decreased.
Conclusion: Experimental NAFLD is characterized by increased oxidant stress accompanying fatty tissue in the liver. Analysis of thiol/disulfide homeostasis parameters in NAFLD can be used in further studies to develop effective treatment options.
목차
등록된 정보가 없습니다.
참고문헌 (30)
참고문헌 신청
Cohen JC / 2011 / Human fatty liver disease : old questions and new insights / Science 332:1519~1523
Ludwig J / 1980 / Nonalcoholic steatohepatitis : Mayo Clinic experiences with a hitherto unnamed disease / Mayo Clin Proc 55:434~438
Arab JP / 2018 / Recent insights into the pathogenesis of nonalcoholic fatty liver disease / Annu Rev Pathol 13:321~350
Di Sessa A / 2019 / Pediatric non-alcoholic fatty liver disease : current perspectives on diagnosis and management / Pediatric Health Med Ther 10:89~97
Chakravarthy MV / 2020 / The metabolic basis of nonalcoholic steatohepatitis / Endocrinol Diabetes Metab 3:e00112
Ludwig J / 1980 / Nonalcoholic steatohepatitis : Mayo Clinic experiences with a hitherto unnamed disease / Mayo Clin Proc 55:434~438
Arab JP / 2018 / Recent insights into the pathogenesis of nonalcoholic fatty liver disease / Annu Rev Pathol 13:321~350
Di Sessa A / 2019 / Pediatric non-alcoholic fatty liver disease : current perspectives on diagnosis and management / Pediatric Health Med Ther 10:89~97
Chakravarthy MV / 2020 / The metabolic basis of nonalcoholic steatohepatitis / Endocrinol Diabetes Metab 3:e00112
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