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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,151 - 1,160 (10page)
- DOI
- 10.3803/EnM.2021.1331
이용수
초록· 키워드
오류제보하기
The liver is a vital organ that regulates systemic energy metabolism and many physiological functions. Nonalcoholic fatty liver disease (NAFLD) is the commonest cause of chronic liver disease and end-stage liver failure. NAFLD is primarily caused by metabolic disruption of lipid and glucose homeostasis. Serotonin (5-hydroxytryptamine [5-HT]) is a biogenic amine with several functions in both the central and peripheral systems. 5-HT functions as a neurotransmitter in the brain and a hormone in peripheral tissues to regulate systemic energy homeostasis. Several recent studies have proposed various roles of 5-HT in hepatic metabolism and inflammation using tissue-specific knockout mice and 5-HT-receptor agonists/antagonists. This review compiles the most recent research on the relationship between 5-HT and hepatic metabolism, and the role of 5-HT signaling as a potential therapeutic target in NAFLD.
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등록된 정보가 없습니다.
참고문헌 (72)
참고문헌 신청
Abai B / 2021 / StatPearls / StatPearls Publishing
Fotbolcu H / 2016 / Nonalcoholic fatty liver disease as a multi-systemic disease / World J Gastroenterol 22:4079~4090
Ferguson D / 2021 / Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus / Nat Rev Endocrinol 17:484~495
Byrne CD / 2015 / NAFLD : a multisystem disease / J Hepatol 62(1 Suppl):S47~64
Chao HW / 2019 / Homeostasis of glucose and lipid in non-alcoholic fatty liver disease / Int J Mol Sci 20:298
Fotbolcu H / 2016 / Nonalcoholic fatty liver disease as a multi-systemic disease / World J Gastroenterol 22:4079~4090
Ferguson D / 2021 / Emerging therapeutic approaches for the treatment of NAFLD and type 2 diabetes mellitus / Nat Rev Endocrinol 17:484~495
Byrne CD / 2015 / NAFLD : a multisystem disease / J Hepatol 62(1 Suppl):S47~64
Chao HW / 2019 / Homeostasis of glucose and lipid in non-alcoholic fatty liver disease / Int J Mol Sci 20:298
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