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논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2021.12
- 수록면
- 1,232 - 1,242 (11page)
- DOI
- https://doi.org/10.3803/EnM.2021.1087
이용수
초록· 키워드
오류제보하기
Background: The prevalence of non-alcoholic fatty liver disease (NAFLD) has rapidly increased worldwide. The aim of this study was to investigate whether there is an independent relationship between regional fat distribution, especially leg fat mass, and the presence of NAFLD using nationally representative data in Korea.
Methods: This cross-sectional study analyzed data from 14,502 participants in the Korea National Health and Nutrition Examination Survey 2008 to 2011. Total fat mass, leg fat mass, and appendicular skeletal muscle mass were measured by dual-energy X-rayabsorptiometry. Validated NAFLD prediction models and scoring systems for hepatic fibrosis were used.
Results: The leg fat to total fat (LF/TF) ratio showed a negative relationship with many factors, including body mass index, waistcircumference, blood pressure, fasting blood glucose, and liver enzyme levels. When the LF/TF ratio and indices of hepatic steatosis were stratified by quartiles, the LF/TF ratio showed a negative correlation with the scoring systems that were used. The LF/TF ratio showed better accuracy in predicting NAFLD than total fat mass or leg fat mass alone. After adjusting for various traditional and lifestyle factors, a low LF/TF ratio remained a risk factor for NAFLD. Among NAFLD subjects, the LF/TF ratio showed a negative relationship with hepatic fibrosis.
Conclusion: A lower LF/TF ratio was markedly associated with a higher risk of hepatic steatosis and advanced hepatic fibrosis using various predictive models in a Korean population. Therefore, the LF/TF ratio could be a useful anthropometric parameter to predict NAFLD or advanced hepatic fibrosis.
목차
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참고문헌 (40)
참고문헌 신청
Rinella ME / 2015 / Nonalcoholic fatty liver disease : a systematic review / JAMA 313:2263~2273
Loomba R / 2013 / The global NAFLD epidemic / Nat Rev Gastroenterol Hepatol 10:686~690
Vernon G / 2011 / Systematic review : the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Ali-ment Pharmacol Ther 34:274~285
이은정 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective / Endocrinology and Metabolism 34(3):226~233
한유진 / 2017 / Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases / Diabetes and Metabolism Journal 41(6):430~437
Loomba R / 2013 / The global NAFLD epidemic / Nat Rev Gastroenterol Hepatol 10:686~690
Vernon G / 2011 / Systematic review : the epidemiology and natural history of non-alcoholic fatty liver disease and non-alcoholic steatohepatitis in adults / Ali-ment Pharmacol Ther 34:274~285
이은정 / 2019 / Nonalcoholic Fatty Liver Disease and Diabetes: An Epidemiological Perspective / Endocrinology and Metabolism 34(3):226~233
한유진 / 2017 / Non-Alcoholic Fatty Liver Disease: The Emerging Burden in Cardiometabolic and Renal Diseases / Diabetes and Metabolism Journal 41(6):430~437
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