지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2017.12
- 수록면
- 174 - 192 (19page)
- DOI
- https://doi.org/10.1186/s40824-017-0106-6
이용수
초록· 키워드
오류제보하기
Background: Intervertebral disc degeneration has an annual worldwide socioeconomic impact masked as low back pain of over 70 billion euros. This disease has a high prevalence over the working age class, which raises the socioeconomic impact over the years. Acute physical trauma or prolonged intervertebral disc mistreatment triggers a biochemical negative tendency of catabolic-anabolic balance that progress to a chronic degeneration disease. Current biomedical treatments are not only ineffective in the long-run, but can also cause degeneration to spread to adjacent intervertebral discs. Regenerative strategies are desperately needed in the clinics, such as: minimal invasive nucleus pulposus or annulus fibrosus treatments, total disc replacement, and cartilaginous endplates decalcification. Main body: Herein, it is reviewed the state-of-the-art of intervertebral disc regeneration strategies from the perspective of cells, scaffolds, or constructs, including both popular and unique tissue engineering approaches. The premises for cell type and origin selection or even absence of cells is being explored. Choice of several raw materials and scaffold fabrication methods are evaluated. Extensive studies have been developed for fully regeneration of the annulus fibrosus and nucleus pulposus, together or separately, with a long set of different rationales already reported. Recent works show promising biomaterials and processing methods applied to intervertebral disc substitutive or regenerative strategies. Facing the abundance of studies presented in the literature aiming intervertebral disc regeneration it is interesting to observe how cartilaginous endplates have been extensively neglected, being this a major source of nutrients and water supply for the whole disc. Conclusion: Several innovative avenues for tackling intervertebral disc degeneration are being reported ? from acellular to cellular approaches, but the cartilaginous endplates regeneration strategies remain unaddressed. Interestingly, patientspecific approaches show great promise in respecting patient anatomy and thus allow quicker translation to the clinics in the near future.
목차
등록된 정보가 없습니다.
참고문헌 (139)
참고문헌 신청
Chang-Qing Zhao / 2007 / The cell biology of intervertebral disc aging and degeneration / Ageing Research Reviews 6(3):247~261
Joshua P. Jarman / 2015 / Intervertebral disc height loss demonstrates the threshold of major pathological changes during degeneration / European Spine Journal 24(9):1944~1950
Abbie LA Binch / 2014 / Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration / Arthritis Research & Therapy 16(4):416
Coventry MB / 1945 / The intervertebral disc: its microscopic anatomy and pathology part i. anatomy, development, and physiology / J bone Jt Surg 27:105~112
Delphine Périé / 2005 / Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability / Journal of Biomechanics 38(11):2164~2171
Joshua P. Jarman / 2015 / Intervertebral disc height loss demonstrates the threshold of major pathological changes during degeneration / European Spine Journal 24(9):1944~1950
Abbie LA Binch / 2014 / Expression and regulation of neurotrophic and angiogenic factors during human intervertebral disc degeneration / Arthritis Research & Therapy 16(4):416
Coventry MB / 1945 / The intervertebral disc: its microscopic anatomy and pathology part i. anatomy, development, and physiology / J bone Jt Surg 27:105~112
Delphine Périé / 2005 / Confined compression experiments on bovine nucleus pulposus and annulus fibrosus: sensitivity of the experiment in the determination of compressive modulus and hydraulic permeability / Journal of Biomechanics 38(11):2164~2171
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