지원사업
학술연구/단체지원/교육 등 연구자 활동을 지속하도록 DBpia가 지원하고 있어요.
커뮤니티
연구자들이 자신의 연구와 전문성을 널리 알리고, 새로운 협력의 기회를 만들 수 있는 네트워킹 공간이에요.
논문 기본 정보
- 자료유형
- 학술저널
- 저자정보
- 발행연도
- 2019.1
- 수록면
- 527 - 534 (8page)
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Study Design: Observational comparative study. Purpose: To compare fractional anisotropy (FA) maps with T2 values of the nucleus pulposus (NP) and annulus fibrosus (AF) of intervertebral discs in healthy volunteers and patients to develop a predictive disc health scale. Overview of Literature: T2-weighted magnetic resonance imaging (MRI) is not sensitive to early morphological changes and provides no quantitative biomarker profile for early degeneration. Methods: We examined 59 healthy controls and 59 patients with back pain by MRI using T2 relaxometry and diffusion tensor imaging (DTI). Each group was divided into three age subgroups: A (<30 years, n=12); B (30–50 years, n=26); and C (>50 years, n=21). We obtained FA values for AF and NP and T2 values for NP for each intervertebral disc. Furthermore, we calculated the FA (AF/NP) ratios. Results: We categorized 590 intervertebral discs from 118 participants, 566 of which were analyzed with T2 relaxometry and DTI. The T2 values were as follows: subgroup A, 55.8±4.4 ms; B, 48.5±6.9 ms; C, 45.8±8.7 ms (p <0.050). The T2 values for the healthy controls of the subgroups A, B, and C were >120 ms, 90–100 ms, and 70 ms, respectively (p <0.001). Control subgroup A had higher T2 values and AF/NP ratios than subgroups B and C; the AF values were not significantly different. Control subgroup B had higher T2 values and AF/NP ratios than subgroup C but lower FA (NP). Conclusions: FA maps of the AF/NP ratio and T2 values of NP are potential microstructure biomarkers of normal and degenerating discs and can help detect early degeneration using a predictive disc health score on a continuous scale.
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참고문헌 (30)
참고문헌 신청
Marinelli NL / 2009 / T2 relaxation times of intervertebral disc tissue correlated with water content and proteoglycan content / Spine(Phila Pa 1976) 34:520~524
Wang C / 2007 / Advances in magnetic resonance imaging for the assessment of degenerative disc disease of the lumbar spine / Semin Spine Surg 19:65~71
Bernick S / 1991 / Age changes to the anulus fibrosus in human intervertebral discs / Spine(Phila Pa 1976) 16:520~524
Lotz JC / 2012 / New treatments and imaging strategies in degenerative disease of the intervertebral disks / Radiology 264:6~19
Marchand F / 1990 / Investigation of the laminate structure of lumbar disc anulus fibrosus / Spine(Phila Pa 1976) 15:402~410
Wang C / 2007 / Advances in magnetic resonance imaging for the assessment of degenerative disc disease of the lumbar spine / Semin Spine Surg 19:65~71
Bernick S / 1991 / Age changes to the anulus fibrosus in human intervertebral discs / Spine(Phila Pa 1976) 16:520~524
Lotz JC / 2012 / New treatments and imaging strategies in degenerative disease of the intervertebral disks / Radiology 264:6~19
Marchand F / 1990 / Investigation of the laminate structure of lumbar disc anulus fibrosus / Spine(Phila Pa 1976) 15:402~410
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