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논문 기본 정보

자료유형
학술저널
저자정보
Markus Göttlicher (Justus-Liebig-University of Giessen Germany) Marcus Rohnke (Justus-Liebig-University of Giessen Germany) Yannik Moryson (Justus-Liebig-University of Giessen Germany) Jürgen Thomas (IFW Dresden Germany) Joachim Sann (Justus-Liebig-University of Giessen Germany) Anja Lode (Technische Universität Dresden) Matthias Schumacher (Technische Universität Dresden) Romy Schmidt (IFW Dresden Germany) Stefan Pilz (IFW Dresden Germany) Annett Gebert (IFW Dresden Germany) Thomas Gemming (IFW Dresden Germany) Jürgen Janek (Justus-Liebig-University of Giessen Germany)
저널정보
한국생체재료학회 생체재료학회지 생체재료학회지 제21권 제4호
발행연도
2017.12
수록면
193 - 203 (11page)
DOI
https://doi.org/10.1186/s40824-017-0104-8

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Background: Surface functionalization of orthopedic implants with pharmaceutically active agents is a modern approach to enhance osseointegration in systemically altered bone. A local release of strontium, a verified bone building therapeutic agent, at the fracture site would diminish side effects, which could occur otherwise by oral administration. Strontium surface functionalization of specially designed titanium-niobium (Ti-40Nb) implant alloy would provide an advanced implant system that is mechanically adapted to altered bone with the ability to stimulate bone formation. Methods: Strontium-containing coatings were prepared by reactive sputtering of strontium chloride (SrCl2) in a self-constructed capacitively coupled radio frequency (RF) plasma reactor. Film morphology, structure and composition were investigated by scanning electron microscopy (SEM), time of flight secondary ion mass spectrometry (ToF-SIMS) and X-ray photoelectron spectroscopy (XPS). High-resolution transmission electron microscopy (HR-TEM) was used for the investigation of thickness and growth direction of the product layer. TEM lamellae were prepared using the focused ion beam (FIB) technique. Bioactivity of the surface coatings was tested by cultivation of primary human osteoblasts and subsequent analysis of cell morphology, viability, proliferation and differentiation. The results are correlated with the amount of strontium that is released from the coating in biomedical buffer solution, quantified by inductively coupled plasma mass spectrometry (ICP-MS). Results: Dense coatings, consisting of SrOxCly, of more than 100 nm thickness and columnar structure, were prepared. TEM images of cross sections clearly show an incoherent but well-structured interface between coating and substrate without any cracks. Sr2+ is released from the SrOxCly coating into physiological solution as proven by ICP-MS analysis. Cell culture studies showed excellent biocompatibility of the functionalized alloy. Conclusions: Ti-40Nb alloy, a potential orthopedic implant material for osteoporosis patients, could be successfully plasma coated with a dense SrOxCly film. The material performed well in in vitro tests. Nevertheless, the Sr2+ release must be optimized in future work to meet the requirements of an effective drug delivery system.
#Surface coating #Titanium alloy #Osteoporosis #Strontium release #Biocompatibility #Plasma deposition

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참고문헌 (34)

참고문헌 신청
Van Noort RJ / 1987 / Titanium: The implant material of today / Mater Sci 22:3801~3811 google schola Niinomi M / 2011 / Titanium-Based Biomaterials for Preventing Stress Shielding between Implant Devices and Bone / Int J Biomater :1~10 google schola Liu X / 2004 / Surface modification of titanium, titanium alloys, and related materials for biomedical applications / Mater Sci Eng R 47:49~121 google schola Lane NE / 2006 / Epidemiology, etiology, and diagnosis of osteoporosis / Am J Obstet Gynecol 194:S3~S11 google schola Cole ZA / 2008 / Osteoporosis epidemiology update / Curr Rheumatol Rep 10:92~96 google schola

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